MLST8: A Potential Drug Target and Biomarker for Various Diseases

Target Name: MLST8

NCBI ID: G64223

MLST8

MLST8: A Potential Drug Target and Biomarker for Various Diseases

MLST8, also known as MTOR associated protein, LST8 homolog, and transcript variant 1, is a protein that is expressed in various tissues and cell types in the human body. It is a member of the MLST family of proteins, which are known for their role in cell signaling pathways. In this article, we will discuss MLST8 as a potential drug target and its potential as a biomarker for various diseases.

Overview of MLST8

MLST8 is a protein that is expressed in various tissues and cell types, including muscle, brain, and heart. It is a member of the MLST family of proteins, which are known for their role in cell signaling pathways. The MLST family consists of seven proteins, including MLST1, MLST2, MLST3, MLST4, MLST5, MLST6, and MLST7. All of these proteins share a similar structural domain, which consists of a single transmembrane domain and a cytoplasmic tail.

Function of MLST8

MLST8 is involved in various cellular processes in the body, including cell signaling, cell division, and cell survival. One of the well-known functions of MLST8 is its role in the regulation of cell signaling pathways. MLST8 is a component of the Mammalian Target of rapamycin (MTOR) complex, which is a protein-protein interaction network that regulates various cellular processes in the body.

The MTOR complex plays a crucial role in the regulation of cell signaling pathways, including cell growth, cell division, and apoptosis. The MTOR complex is composed of several proteins, includingMTOR, ATG5, and p70S6. MLST8 is one of the key components of the MTOR complex, and it functions as a negative regulator of the MTOR signaling pathway.

MLST8 is also involved in the regulation of cell division. During cell division, MLST8 plays a role in the maintenance of cell pluripotency and the regulation of cell division. It is known to interact with the transcription factor, p21, which is involved in the regulation of cell growth and apoptosis.

In addition to its role in cell signaling pathways, MLST8 is also involved in the regulation of cell survival. The MTOR signaling pathway has been shown to play a role in the regulation of cell survival and apoptosis. MLST8 is known to interact with the protein, BCL2, which is involved in the regulation of cell apoptosis.

Potential as a Drug Target

MLST8 has been identified as a potential drug target due to its involvement in various cellular processes that are affected by various diseases. One of the main reasons for its potential as a drug target is its involvement in the regulation of cell signaling pathways. Many diseases, including cancer, are caused by the regulation of cell signaling pathways gone awry. Therefore, targeting MLST8 with drugs that can modulate its function could be an effective way to treat these diseases.

Another potential mechanism by which MLST8 can be targeted with drugs is its role in cell division. Many diseases, including neurodegenerative disorders, are caused by the regulation of cell division gone awry. Therefore, targeting MLST8 with drugs that can modulate its function could be an effective way to treat these diseases.

Potential as a Biomarker

MLST8 has also been identified as a potential biomarker for various diseases. The MTOR signaling pathway is involved in the regulation of various cellular processes, including cell growth, cell division, and apoptosis. Therefore, changes in the level of MLST8 expression could be an indicator of the regulation of

Protein Name: MTOR Associated Protein, LST8 Homolog

Functions: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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