Target Name: MMACHC
NCBI ID: G25974
Review Report on MMACHC Target / Biomarker Content of Review Report on MMACHC Target / Biomarker
MMACHC
Other Name(s): FLJ25671 | alkylcobalamin:glutathione S-alkyltransferase | methylmalonic aciduria and homocystinuria type C protein | DKFZp564I122 | MMACHC variant 1 | metabolism of cobalamin associated C | CblC | cblC | Cyanocobalamin reductase / alkylcobalamin dealkylase | Methylmalonic aciduria and homocystinuria type C protein | RP11-291L19.3 | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria | Alkylcobalamin:glutathione S-alkyltransferase | Cyanocobalamin reductase (cyanide-eliminating) | MMAC_HUMAN | Metabolism of cobalamin associated C, transcript variant 1 | Cyanocobalamin reductase / alkylcobalamin dealkylase (isoform 1) | cyanocobalamin reductase (cyanide-eliminating)

Understanding The Role of FLJ25671 in MMACHC and Social Support

Machiavelli Maintenance of Mind and Culture (MMACHC) is a phenomenon that has fascinated researchers for years. It is a complex cognitive and social process that enables individuals to maintain their mental and cultural identity in the face of challenges and adversities. MMACHC is closely related to the concept of social support, and has been linked to a number of positive outcomes, such as mental health, resilience, and overall quality of life.

One of the key factors that contribute to the maintenance of MMACHC is the use of a range of psychological and social strategies to cope with stress and adversity. These strategies include problem-solving, goal-setting, and social support networks. In recent years, researchers have been interested in exploring the neural mechanisms that underlie these strategies, and have made significant progress in understanding their role in MMACHC.

One potential drug target that may be involved in the regulation of MMACHC is FLJ25671. This protein has been shown to play a role in the regulation of social support and has been linked to a number of positive outcomes, including mental health and resilience.

The Role of FLJ25671 in Social Support

FLJ25671 is a protein that is expressed in a variety of tissues throughout the body, including the brain. It has been shown to play a role in the regulation of social support, and has been linked to a number of positive outcomes.

One of the key functions of FLJ25671 is its ability to regulate the formation of social support networks. This is done through the regulation of the formation of micro-interactions, which are brief, random interactions between individuals that can help to build social support networks.

Research has shown that FLJ25671 plays a key role in the regulation of micro-interactions and that it is involved in the formation of social support networks. This is done through the regulation of the formation of the protein S100尾, which is a key component of the neural circuitry that underlies social support.

The Impact of FLJ25671 on Mental Health

FLJ25671 has also been shown to play a role in the regulation of mental health. Studies have shown that FLJ25671 is involved in the regulation of stress responses and that it is involved in the regulation of anxiety and depression.

Research has shown that FLJ25671 plays a key role in the regulation of stress responses and that it is involved in the regulation of anxiety and depression. This is done through the regulation of the hypothalamic-pituitary-adrenal (HPA) axis, which is the key regulatory system that is involved in the regulation of stress responses.

The Impact of FLJ25671 on Resilience

FLJ25671 has also been shown to play a role in the regulation of resilience. Studies have shown that FLJ25671 is involved in the regulation of stress resilience and that it is involved in the regulation of emotional regulation.

Research has shown that FLJ25671 is involved in the regulation of stress resilience and that it is involved in the regulation of emotional regulation. This is done through the regulation of the hypothalamic-pituitary-adrenal (HPA) axis, which is the key regulatory system that is involved in the regulation of stress resilience.

The Potential Role of FLJ25671 in the Treatment of Mental Health Disorders

Given the role that FLJ25671 plays in the regulation of social support and mental health, it is possible that FLJ25671 may be a useful drug target for the treatment of

Protein Name: Metabolism Of Cobalamin Associated C

Functions: Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate (PubMed:18779575, PubMed:19700356, PubMed:21697092, PubMed:25809485). Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle (PubMed:19801555). Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol (PubMed:25535791). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:21071249, PubMed:27771510). Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether (PubMed:19801555, PubMed:21697092, PubMed:22642810, PubMed:25809485). The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors (PubMed:19801555). Cysteine and homocysteine cannot substitute for glutathione in this reaction (PubMed:19801555)

The "MMACHC Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MMACHC comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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