Understanding and Potential Uses of PPP2A (G5519)

Target Name: PPP2R1B

NCBI ID: G5519

PPP2R1B

Other Name(s): PP2A, subunit A, PR65-beta isoform | PPP2R1B variant 2 | Protein phosphatase 2 scaffold subunit Abeta, transcript variant 2 | PP2A subunit A isoform PR65-beta | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (isoform b) | Protein Phosphatase 2A (PP-2A) | Protein phosphatase 2 (formerly 2A), regulatory subunit A, eta isoform | Protein phosphatase 2 scaffold subunit Abeta, transcript variant 4 | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (isoform a) | protein phosphatase 2, structural/regulatory subunit A, beta | protein phosphatase 2, regulatory subunit A, beta | PP2A subunit A isoform R1-beta | PR65B | PP2A-Abeta | protein phosphatase 2 scaffold subunit Abeta | Protein phosphatase 2 scaffold subunit Abeta, transcript variant 1 | Protein phosphatase 2, structural/regulatory subunit A, beta | Beta isoform of regulatory subunit A, protein phosphatase 2 | PPP2R1B variant 4 | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (isoform d) | Protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform | Protein phosphatase 2, regulatory subunit A, beta | PPP2R1B variant 1 | 2AAB_HUMAN | PP2A, subunit A, R1-beta isoform

Understanding and Potential Uses of PPP2A

PP2A (phosphatidylinositol 2-kinase, subunit A) is a protein that plays a critical role in cell signaling pathways, particularly in the regulation of cell adhesion, migration, and invasion. It is a key component of the PI3K/Akt signaling pathway, which is a well-established pathway involved in various cellular processes, including cell survival, growth, and angiogenesis. The PPP2A protein has also been implicated in the development and progression of various diseases, including cancer. As a result, there is a growing interest in the development of drugs that target PPP2A.

In this article, we will focus on PPP2A (PP2A, subunit A, PR65-beta isoform), which is a protein that is well-studied and has potential as a drug target. We will review the current understanding of PPP2A and its role in cell signaling pathways, as well as the current research on the potential uses of PPP2A as a drug.

Current Understanding of PPP2A

PP2A is a 21-kDa protein that is expressed in various tissues and cell types. It is a key component of the PI3K/Akt signaling pathway, which is a well-established pathway involved in various cellular processes, including cell survival, growth, and angiogenesis. The PPP2A protein has a catalytic active site that is involved in the formation of the intermembrane phosphate ion (IP) and a catalytic basic site that is involved in the hydrolysis of the IP.

In cell signaling pathways, PPP2A plays a critical role in the regulation of cell adhesion, migration, and invasion. It is involved in the formation of tight junctions, which are a type of cell-cell adhesion that is critical for the proper functioning of tissues and organs. PPP2A is also involved in the regulation of cell migration, which is critical for the development and progression of tissues and organs. In addition, PPP2A is involved in the regulation of cell invasion, which is critical for the development of cancer.

In addition to its role in cell signaling pathways, PPP2A is also implicated in the development and progression of various diseases. For example, PPP2A has been implicated in the development of cancer, including breast and colorectal cancers. In addition, PPP2A has been implicated in the development of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

Potential Uses of PPP2A as a Drug Target

As a result of its role in cell signaling pathways and its involvement in the development and progression of various diseases, there is a growing interest in the development of drugs that target PPP2A. Currently, there are several drugs that are being developed that target PPP2A, including inhibitors of the PPP2A kinase, PPP2A-specific antibodies, and PPP2A-targeted small molecules.

One of the most promising drugs that targets PPP2A is a small molecule inhibitor called PPI-061012. This drug is currently being tested in clinical trials for the treatment of various cancers, including breast, lung, and ovarian cancers. In these trials, PPI-061012 has been shown to inhibit the activity of the PPP2A kinase and to reduce the growth of cancer cells.

Another drug that targets PPP2A is a monoclonal antibody called AEB121207. This antibody is designed to selectively bind to and inhibit the activity of PPP2A,

Protein Name: Protein Phosphatase 2 Scaffold Subunit Abeta

Functions: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit

The "PPP2R1B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PPP2R1B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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