Potential Therapeutic Applications of PR130/B''alpha1 Subunit

Target Name: PPP2R3A

NCBI ID: G5523

PPP2R3A

Other Name(s): PR130/B''alpha1 subunit | protein phosphatase 2, regulatory subunit B'', alpha | PR130 | Protein phosphatase 2 regulatory subunit B''alpha, transcript variant 1 | Protein phosphatase 2 (formerly 2A),

Potential Therapeutic Applications of PR130/B''alpha1 Subunit

PR130/B''alpha1 subunit is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. Its function is not well understood, but it is known to play a role in the regulation of ion channels and neurotransmitter release. Recently, research has suggested that PR130/B''alpha1 subunit may be a drug target or biomarker for various neurological and psychiatric disorders. In this article, we will explore the biology and potential therapeutic applications of PR130/B''alpha1 subunit.

Structure and Expression

PR130/B''alpha1 subunit is a transmembrane protein that consists of 118 amino acids. It has a molecular weight of 13.9 kDa and an estimated pI of 8.0. PR130/B''alpha1 subunit is expressed in various tissues of the body, including the brain, heart, and kidneys. It is highly expressed in the brain, with a protein expression of 100% in the brain tissue.

Function

PR130/B''alpha1 subunit is involved in the regulation of ion channels and neurotransmitter release. It has been shown to interact with various ion channels, including the Na+, K+, and Ca2+ channels. It is also involved in the regulation of neurotransmitter release, including the release of dopamine, a neurotransmitter that is involved in various psychiatric and neurological disorders.

Potential Therapeutic Applications

The potential therapeutic applications of PR130/B''alpha1 subunit are vast. Given its involvement in the regulation of ion channels and neurotransmitter release, PR130/B''alpha1 subunit may be a drug target for various neurological and psychiatric disorders.

1. Parkinson's disease: Parkinson's disease is a neurodegenerative disorder that is characterized by the loss of dopamine-producing neurons in the brain. PR130/B''alpha1 subunit has been shown to interact with dopamine-producing neurons and may play a role in the regulation of dopamine release in these neurons. Therefore, PR130/B''alpha1 subunit may be a potential therapeutic target for Parkinson's disease.
2. Depression: Depression is a common psychiatric disorder that is characterized by the loss of interest in previously enjoyable activities. PR130/B''alpha1 subunit has been shown to play a role in the regulation of ion channels in the brain, including the regulation of serotonin receptors. Therefore, PR130/B''alpha1 subunit may be a potential therapeutic target for depression.
3. Bipolar disorder: Bipolar disorder is a psychiatric disorder that is characterized by the episodes of mania and depression. PR130/B''alpha1 subunit has been shown to play a role in the regulation of ion channels in the brain, including the regulation of dopamine receptors. Therefore, PR130/B''alpha1 subunit may be a potential therapeutic target for Bipolar disorder.
4. Alzheimer's disease: Alzheimer's disease is a neurodegenerative disorder that is characterized by the loss of memory and cognitive decline. PR130/B''alpha1 subunit has been shown to play a role in the regulation of ion channels in the brain, including the regulation of neurotransmitter release. Therefore, PR130/B''alpha1 subunit may be a potential therapeutic target for Alzheimer's disease.

Conclusion

PR130/B''alpha1 subunit is a protein that is involved in the regulation of ion channels and neurotransmitter release. Its function is not well understood, but it is known to play a role in the regulation of various physiological processes in the body. Recently, research has suggested that PR130/B''alpha1 subunit may be a drug target or biomarker for various neurological and psychiatric disorders. Further research is needed to fully understand the potential therapeutic applications of PR130/B''alpha1 subunit.

Protein Name: Protein Phosphatase 2 Regulatory Subunit B''alpha

Functions: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment

The "PPP2R3A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PPP2R3A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets