PPP2R5D: for Treating Neurological and Psychiatric Disorders (G5528)

Target Name: PPP2R5D

NCBI ID: G5528

PPP2R5D

PPP2R5D: for Treating Neurological and Psychiatric Disorders

PPP2A B subunit isoform PR61-delta, also known as PPP2R5D, is a protein that plays a crucial role in the regulation of cellular processes in the brain, including neurotransmitter signaling and synaptic plasticity. The PPP2A B subunit isoform is a transmembrane protein that is expressed in various tissues and cell types, including neurons, glial cells, and other neural cell types.

Expression and function

The PPP2A B subunit isoform is expressed in the brain and other nervous tissue and is involved in the regulation of various cellular processes, including neurotransmitter signaling, synaptic plasticity, and cell survival. It is a key component of the PPP2A signaling pathway, which is a well-established regulator of neurotransmitter signaling in the brain.

The PPP2A B subunit isoform plays a crucial role in the regulation of neurotransmitter signaling, specifically in the regulation of dopamine (D2) receptors. Dopamine is a neurotransmitter that plays a crucial role in motor function, motivation, and pleasure. The PPP2A B subunit isoform is known to regulate the trafficking of dopamine receptors from the endoplasmic reticulum (ER) to the cell surface, which is a critical step in the regulation of dopamine signaling.

In addition to its role in neurotransmitter signaling, the PPP2A B subunit isoform is also involved in the regulation of synaptic plasticity, which is the ability of neural circuits to change and adapt over time. The PPP2A B subunit isoform is known to regulate the trafficking of synaptic vesicles, which are responsible for the release of neurotransmitters and other signaling molecules at the synapse, to the cell surface. This regulation is critical for the maintenance of synaptic plasticity and the development of neural circuits.

The PPP2A B subunit isoform is also involved in the regulation of cell survival, specifically in the regulation of neuroblast cells, which are a type of stem cell that play a critical role in the development and maintenance of neural circuits. The PPP2A B subunit isoform is known to regulate the survival of neuroblast cells by regulating the trafficking of neuroblast cells to the apoptosis-associated protein (AP-1) death domain, which is a region of the protein that is involved in cell death.

Drug targeting and biomarker potential

The PPP2A B subunit isoform PR61-delta is a drug target with potential for the treatment of various neurological and psychiatric disorders. The PPP2A B subunit isoform is known to play a crucial role in the regulation of neurotransmitter signaling, including the regulation of dopamine signaling, and is involved in the regulation of synaptic plasticity and cell survival.

The PPP2A B subunit isoform PR61-delta can be targeted with small molecules, such as those that inhibit the activity of the PPP2A B subunit, to prevent the regulation of neurotransmitter signaling, synaptic plasticity, and cell survival. Such targeted therapies have the potential to treat various neurological and psychiatric disorders, including depression, anxiety, and neurodegenerative diseases.

Conclusion

The PPP2A B subunit isoform PR61-delta is a protein that plays a crucial role in the regulation of cellular processes in the brain, including neurotransmitter signaling and synaptic plasticity. It is a key component of the PPP2A signaling pathway and is involved in the regulation of various cellular processes that are critical for the development and maintenance of neural circuits. The PPP2A B subunit isoform PR61-delta is a drug target with potential for the treatment of various neurological and psychiatric disorders.

Protein Name: Protein Phosphatase 2 Regulatory Subunit B'delta

Functions: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment

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