CCDC87: A Potential Drug Target and Biomarker (G55231)

Target Name: CCDC87

NCBI ID: G55231

CCDC87

Other Name(s): coiled-coil domain-containing protein 87 | Coiled-coil domain-containing protein 87 | CCD87_HUMAN | Coiled-coil domain containing 87 | coiled-coil domain containing 87

CCDC87: A Potential Drug Target and Biomarker

CDC87 is a protein that is expressed in various tissues of the human body. Its primary function is to regulate the movement of ions and water molecules into and out of cells. This protein has also been shown to play a role in the development and progression of various diseases, including cancer. As a result, CCDC87 has potential as a drug target or biomarker.

CDC87's Structure and Function

CDC87 is a member of the superfamily of transmembrane proteins, which means that it spans the cell membrane and is associated with various intracellular signaling pathways. It has a single transmembrane domain and a cytoplasmic tail that is involved in its stability and localization to different cell types.

One of the most interesting features of CDC87 is its ability to form a coiled-coil structure. This structure allows the protein to interact with various intracellular signaling pathways, including the TGF-β pathway. The TGF-β pathway is a well-established regulator of cell growth, differentiation, and survival, and is involved in the development and progression of many diseases, including cancer.

CDC87's role in the TGF-β pathway is to regulate the activity of the transcription factor SMAD, which is a key regulator of cell growth and differentiation. By modulating the activity of SMAD, CDC87 has been shown to play a role in the regulation of cell proliferation, apoptosis, and autophagy.

CDC87's Potential as a Drug Target

CDC87's ability to form a coiled-coil structure and its role in the TGF-β pathway make it an attractive target for drug development. One potential approach to targeting CDC87 is to use small molecules that can modulate the activity of SMAD. This could involve inhibiting the activity of SMAD, or increasing the activity of SMAD, depending on the desired effect.

Another potential approach to targeting CDC87 is to use antibodies that specifically recognize and target the protein. This could involve using antibodies that are designed to bind to CDC87 and prevent it from interacting with SMAD. Alternatively, antibodies that recognize and bind to CDC87 could be used to activate SMAD, leading to increased cell proliferation and survival.

CDC87's Potential as a Biomarker

In addition to its potential as a drug target, CCDC87 may also be a useful biomarker for the diagnosis and prognosis of various diseases. Its role in the TGF-β pathway has been implicated in the development and progression of many diseases, including cancer. As a result, changes in the expression of CDC87 may be an indicator of the presence or progression of these diseases.

For example, studies have shown that changes in the expression of CDC87 have been associated with the development of various cancers, including breast, ovarian, and prostate cancers. Additionally, changes in the expression of CDC87 have also been implicated in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

Another potential use of CDC87 as a biomarker is its ability to be affected by small changes in intracellular signaling pathways. For example, small changes in the activity of SMAD have been shown to affect the expression of CDC87. This suggests that changes in the intracellular signaling pathways that involve CDC87 may be an indicator of the presence or progression of certain diseases.

Conclusion

CDC87 is a protein that has been shown to play a role in the development and progression of various diseases, including cancer. Its ability to form a coiled-coil structure and its role in the TGF-β pathway make it an attractive target for drug development. Additionally, changes in the expression of CDC87 may be an indicator of the presence or progression of

Protein Name: Coiled-coil Domain Containing 87

Functions: Plays a role in spermatogenesis, where it is important for normal sperm head morphology. Also required for the acrosome reaction and thus normal male fertility

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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