PIP4K2C: A Drug Target for Improving Energy Production (G79837)

Target Name: PIP4K2C

NCBI ID: G79837

PIP4K2C

Other Name(s): PIP5K2C | PI42C_HUMAN | phosphatidylinositol-4-phosphate 5-kinase, type II, gamma | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | PIP4K2C variant 1 | phosphatidylinositol-5-phosphate 4-kinase type 2 gamma | Phosphatidylinositol-5-phosphate 4-kinase type II gamma | phosphatidylinositol 4-phosphate 5-kinase | FLJ22055 | phosphatidylinositol 5-phosphate 4-kinase type II gamma | Phosphatidylinositol-5-phosphate 4-kinase type 2 gamma, transcript variant 1 | PIP4KII-gamma | PI(5)P 4-kinase type II gamma | Phosphatidylinositol 5-phosphate 4-kinase type II gamma | Phosphatidylinositol 4-phosphate 5-kinase | Phosphatidylinositol-4-phosphate 5-kinase, type II, gamma | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (isoform a)

PIP4K2C: A Drug Target for Improving Energy Production

PIP4K2C (Pyruvate Kinase 4 Kinase 2 Component) is a protein that is expressed in various tissues and cells in the human body. It plays a crucial role in the metabolism of pyruvate, which is a critical amino acid that is involved in the citric acid cycle , also known as the Krebs cycle or tricarboxylic acid (TCA) cycle. This protein is a key player in the regulation of the citric acid cycle, and is involved in the transfer of pyruvate to the cytosol, where it can be used for energy by the cell.

The PIP4K2C gene was first identified in 1995, and it encodes a protein that has a molecular weight of approximately 43 kDa. This protein is a member of the PIP4K2 family, which includes several related proteins that are involved in the regulation of the citric acid cycle . The PIP4K2C protein is expressed in various tissues and cells, including muscle, heart, liver, and brain.

PIP4K2C function

PIP4K2C is a key protein that is involved in the regulation of the citric acid cycle. It plays a crucial role in the transfer of pyruvate to the cytosol, where it can be used for energy by the cell. During the citric acid cycle, pyruvate is produced from the citric acid cycle intermediates, such as citrate and fumarate. Pyruvate is then transferred to the cytosol, where it can be used for energy by the cell through the citric acid cycle.

PIP4K2C is involved in the regulation of the citric acid cycle at multiple levels. Firstly, it is involved in the regulation of the rate at which pyruvate is produced from the citric acid cycle intermediates. This is achieved through its role in the regulation of the activity of the E1-subunit of the succinyl-CoA synthetase, which is the first step in the citric acid cycle.

Secondly, PIP4K2C is involved in the regulation of the rate at which pyruvate is removed from the cytosol. This is achieved through its role in the regulation of the activity of the Pyruvate Transporter, which is responsible for transporting pyruvate out of the cytosol and into the mitochondria.

Finally, PIP4K2C is involved in the regulation of the rate at which the citric acid cycle intermediates are converted to their final products. This is achieved through its role in the regulation of the activity of the citric acid cycle enzyme, known as the succinyl-CoA synthetase.

Drug targeting

PIP4K2C is a drug target of interest, and various studies have investigated its potential as a potential therapeutic agent. One of the main targets of PIP4K2C is the inhibition of its activity, as this can have a beneficial effect on the citric acid cycle and potentially lead to improve energy production by the cell.

The most promising strategy for targeting PIP4K2C is the inhibition of its activity with small molecules, such as those that can inhibit the succinyl-CoA synthetase. Several studies have shown that inhibitors of the succinyl-CoA synthetase have a beneficial effect on the citric acid cycle and can improve energy production by the cell. These inhibitors can also have a beneficial effect on the expression of PIP4K2C, as shown by several studies.

Another approach to targeting PIP4K2C is the use of genetic modification, such as the use of CRISPR/Cas9 to knockdown the expression of PIP4K2C. This can be

Protein Name: Phosphatidylinositol-5-phosphate 4-kinase Type 2 Gamma

Functions: Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439)

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