PIP5K1A: A Potential Drug Target and Biomarker for Treatment of Inflammatory Neurodegenerative Diseases

Target Name: PIP5K1A

NCBI ID: G8394

PIP5K1A

Other Name(s): PI51A_HUMAN | 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha | PtdIns(4)P-5-kinase 1 alpha | OTTHUMP00000196331 | PIP5K1A variant 3 | PIP5KIalpha | phosphatidylinositol 4-phosphate 5-kinase type I alpha | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (isoform 1) | Phosphatidylinositol-4-phosphate 5-kinase type I alpha | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (isoform 3) | ptdIns(4)P-5-kinase 1 alpha | Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha, transcript variant 3 | 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha | Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha, transcript variant 1 | phosphatidylinositol-4-phosphate 5-kinase type 1 alpha | Phosphatidylinositol 4-phosphate 5-kinase type I alpha | PIP5K1-alpha | PIP5K1A variant 1 | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

PIP5K1A: A Potential Drug Target and Biomarker for Treatment of Inflammatory Neurodegenerative Diseases

Abstract:

PIP5K1A (PI51A_HUMAN) is a protein that has been identified as a potential drug target and biomarker for the treatment of inflammatory neurodegenerative diseases. Its functions and interactions with other proteins have been extensively studied, providing insights into its potential as a therapeutic agent. This article will summarize the current understanding of PIP5K1A, its potential drug targets, and its potential as a biomarker for the diagnosis and treatment of inflammatory neurodegenerative diseases.

Introduction:

Inflammatory neurodegenerative diseases, such as multiple sclerosis, rheumatoid arthritis, and neuroinflammatory diseases, are characterized by the inflammation and damage to the nervous system. These conditions can cause significant morbidity and mortality, making them a major public health issue. There is an ongoing need for effective treatments that can alleviate symptoms, slow disease progression, and improve quality of life.

PIP5K1A: A Potential Drug Target and Biomarker

PIP5K1A is a protein that has been identified as a potential drug target and biomarker for the treatment of inflammatory neurodegenerative diseases. Its functions and interactions with other proteins have been extensively studied, providing insights into its potential as a therapeutic agent.

PIP5K1A is a protein that is expressed in various tissues, including the brain, spinal cord, and peripheral tissues. It is involved in the regulation of protein synthesis, translation, and degradation, making it a potential target for small molecules that can modulate its activity.

PIP5K1A has been shown to play a role in the regulation of immune cells, including T cells and macrophages. It has been shown to facilitate the translocation of immune cells into the central nervous system, where it can contribute to the development and progression of neurodegenerative diseases.

In addition, PIP5K1A has also been shown to play a role in the regulation of neurotransmitter release and synaptic plasticity, which are critical for the function of neurons. Its involvement in these processes makes it a potential target for drugs that can modulate neurotransmitter release and synaptic plasticity.

PIP5K1A as a Biomarker:

PIP5K1A has also been shown to be a potential biomarker for the diagnosis and treatment of inflammatory neurodegenerative diseases. Its expression has been shown to be elevated in the brains of individuals with various neurodegenerative diseases, including multiple sclerosis and rheumatoid arthritis.

In addition, studies have shown that PIP5K1A can be targeted by small molecules, providing insights into its potential as a biomarker for the diagnosis and treatment of these conditions.

Potential Drug Targets:

Based on its functions and interactions with other proteins, PIP5K1A is a potential target for small molecules that can modulate its activity. Some potential small molecules that can interact with PIP5K1A include:

1. Small Molecules: Small molecules that can interact with PIP5K1A include:
* Pyruvate (metabolite)
* Acetyl-CoA (acetyl-CoA carboxylase)
* Pyruvate Carrier Proteins (PCP)
* Pyruvate Dehydrogenase (PDH)
* Pyruvate Transcarrier Proteins (PTP)
* Pyruvate Kinase (PK)
* Pyruvate Pyruvate Transcarrier Proteins (PPTP)
* Pyruvate Phosphate (PP)
* Pyruvate Enzymes (PE)
* Pyruvate synthase (PS)
* Pyruvate-ribosyltransferase (PRT)
* Pyruvate-protein-pyruvate transporter (P2R)
* Pyruvate-pyruvate-glutamyl-peptide (PP)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing)
* Pyruvate-pyruvate-glutamyl-peptide-containing enzyme (PP-containing

Protein Name: Phosphatidylinositol-4-phosphate 5-kinase Type 1 Alpha

Functions: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:8955136, PubMed:21477596, PubMed:22942276). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (PubMed:19158393, PubMed:20660631). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Can also use phosphatidylinositol (PtdIns) as substrate in vitro (PubMed:22942276). Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle ingestion by activating the WAS GTPase-binding protein that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup (By similarity). Together with PIP5K1B, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, IP3 and DAG, that will mobilize internal calcium and drive keratinocyte differentiation (PubMed:19158393). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Together with PIP5K1C has a role during embryogenesis (By similarity). Independently of its catalytic activity, is required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of the small GTPase RAC1 to the plasma membrane (PubMed:20660631). Also functions in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (PubMed:18288197)

The "PIP5K1A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PIP5K1A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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