PSMD4: A Protein Involved in Protein Synthesis and Delivery (G5710)

Target Name: PSMD4

NCBI ID: G5710

PSMD4

PSMD4: A Protein Involved in Protein Synthesis and Delivery

PSMD4 (Proteasome-Mediated Secretory Transport, subfamily M member 4) is a protein that plays a crucial role in the regulation of protein synthesis in eukaryotic cells. It is a member of the PSM family, which includes proteins involved in the delivery and processing of proteins from the endoplasmic reticulum to various cellular compartments. PSMD4 is widely expressed in various tissues and is involved in the delivery of proteins to the cytosol, endoplasmic reticulum, and mitochondria.

PSMD4 functions as a transmembrane protein that is involved in the delivery of proteins to the cytosol, endoplasmic reticulum, and mitochondria. It is a member of the PSM family, which includes proteins involved in the delivery and processing of proteins from the endoplasmic reticulum to various cellular compartments. The PSM family is characterized by the presence of a catalytic center in the form of a nucleotide-binding oligomerization domain (NBO), which is responsible for the transfer of the phosphate group from the cognate nucleotide to the target protein.

PSMD4 is involved in the delivery of a wide variety of proteins to the cytosol, endoplasmic reticulum, and mitochondria. For example, it is involved in the delivery of the protein translocation factor (PTF) to the cytosol, where it can interact with the protein factors that recruitptate the PTF to the endoplasmic reticulum. PSMD4 is also involved in the delivery of the protein heat shock protein (Hsp70) to the cytosol, where it can interact with the protein factors that recruit Hsp70 to the endoplasmic reticulum.

PSMD4 is also involved in the delivery of other proteins to the mitochondria. For example, it is involved in the delivery of the protein folding machinery (Mitofusin) to the mitochondria, where it can interact with the protein factors that recruit Mitofusin to the mitochondria.

PSMD4 is a protein that is widely expressed in various tissues and is involved in the delivery of proteins to the cytosol, endoplasmic reticulum, and mitochondria. Its functions as a transmembrane protein involved in the delivery of proteins to these different cellular compartments are of great interest for the development of new drugs and biomarkers.

In conclusion, PSMD4 is a protein that plays a crucial role in the regulation of protein synthesis in eukaryotic cells. Its functions as a transmembrane protein involved in the delivery of proteins to the cytosol, endoplasmic reticulum, and mitochondria make it an attractive drug target and a potential biomarker for various diseases. Further research is needed to fully understand the role of PSMD4 in protein synthesis and to develop new drugs and biomarkers that target this protein.

Protein Name: Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 4

Functions: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains

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