ZFAT-AS1: A Potential Drug Target and Biomarker (G594840)

Target Name: ZFAT-AS1

NCBI ID: G594840

ZFAT-AS1

Other Name(s): NCRNA00070 | ZFAT antisense RNA 1 | ZFAT-AS | ZFATAS | SAS-ZFAT

ZFAT-AS1: A Potential Drug Target and Biomarker

Introduction

Zinc finger nuclease (ZFAT) is a type of RNA-binding protein widely present in various organisms, which participates in important processes of gene expression and regulation. The ZFAT family includes three genes: ZFAT, ZFAT-AS1 and ZFAT-AS2. ZFAT and ZFAT-AS1 play important roles in plants and some bacteria, while ZFAT-AS2 mainly plays a role in humans and some bacteria. This article focuses on ZFAT-AS1 and explores its potential as a drug target and biomarker.

Drug target potential

The performance of ZFAT-AS1 in drug target screening has attracted widespread attention. Studies have shown that ZFAT-AS1 can be used as a target for anti-tumor drugs. The expression level of ZFAT-AS1 in tumor cells is often high, which makes ZFAT-AS1 a potential tumor treatment target. At the same time, studies have found that the expression level of ZFAT-AS1 is positively correlated with tumor invasion and metastasis, which provides a basis for using ZFAT-AS1 as a target for anti-tumor drugs.

Biomarker potential

ZFAT-AS1 also has potential application value in biomarkers. Biomarkers refer to molecules or cell groups that can reflect certain specific molecules or functional states in organisms. ZFAT-AS1 plays a key role in gene expression and regulation and therefore can serve as a biomarker for certain diseases. For example, some studies have found that ZFAT-AS1 is positively correlated with the degree of liver fibrosis and therefore can be used as a biomarker of liver fibrosis. In addition, ZFAT-AS1 can also be used as a biomarker for certain tumors, such as lung cancer, breast cancer, etc.

structural biology research

In order to deeply explore the biological function of ZFAT-AS1, the researchers studied it through structural biology methods. Research has found that when ZFAT-AS1 functions in vivo, its C-terminus binds to RNA and its N-terminal binds to protein, which makes ZFAT-AS1 have a stable three-dimensional structure in vivo. In addition, the phosphorylation modification of ZFAT-AS1 is also highly conserved, which provides a basis for studying the phosphorylation modification of ZFAT-AS1.

Clinical application prospects

The potential application of ZFAT-AS1 in drug target screening and biomarker research makes ZFAT-AS1 a promising drug target. Currently, researchers are exploring ZFAT-AS1 as a target for anti-tumor drugs in order to provide better treatment options for tumor patients. At the same time, with the in-depth study of the biological function of ZFAT-AS1, the potential of ZFAT-AS1 in other functional fields in the organism can be explored in the future, providing new theoretical support for biomedical research.

Protein Name: ZFAT Antisense RNA 1

The "ZFAT-AS1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZFAT-AS1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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