Target Name: ZMPSTE24
NCBI ID: G10269
Review Report on ZMPSTE24 Target / Biomarker Content of Review Report on ZMPSTE24 Target / Biomarker
ZMPSTE24
Other Name(s): HGPS | Zinc metalloproteinase STE24 | zinc metallopeptidase STE24 | Zinc metallopeptidase STE24 | zinc metallopeptidase STE24 homolog | zinc metalloproteinase Ste24 homolog | Prenyl protein-specific endoprotease 1 | Farnesylated-proteins converting enzyme 1 | OTTHUMP00000006394 | FACE1 | CAAX prenyl protease | Zinc metalloproteinase Ste24 homolog | CAAX prenyl protease 1 homolog | prenyl protein-specific endoprotease 1 | Farnesylated proteins-converting enzyme 1 | farnesylated proteins-converting enzyme 1 | STE24 | Ste24p | PRO1 | FLJ14968 | RSDM1 | FACE1_HUMAN | FACE-1

ZMPSTE24: A Potential Drug Target for MS and Chronic Pain

ZMPSTE24 (Z-myelinated Projection System-24) is a protein that is expressed in the central nervous system (CNS) and is involved in the development and maintenance of the myelin sheath that surrounds and supports nerve cells. ZMPSTE24 has been identified as a potential drug target for various neurological disorders, including multiple sclerosis and chronic pain.

The myelin sheath is a vital structure that helps to insulate and protect nerve cells. In people with multiple sclerosis, the myelin sheath is attacked by the immune system and becomes inflamed, leading to the symptoms of the disease. ZMPSTE24 has been shown to play a role in the development and progression of multiple sclerosis, as well as in the regulation of the immune response.

In addition to its role in multiple sclerosis, ZMPSTE24 has also been shown to be involved in the development and maintenance of other neurological disorders, including chronic pain. Chronic pain is a common condition that can be caused by a variety of factors, including musculoskeletal injuries, neural injuries, and certain neurological disorders. ZMPSTE24 has been shown to play a role in the regulation of pain signaling and the modulation of pain sensitivity.

The potential drug targets for ZMPSTE24 are vast, as the protein has been shown to be involved in a number of different signaling pathways and processes that are involved in the development and maintenance of the myelin sheath and the immune response. One potential drug that may target ZMPSTE24 is a monoclonal antibody that targets the protein. This antibody has been shown to be effective in reducing the symptoms of multiple sclerosis and chronic pain in animal models of the disorders.

Another potential drug that may target ZMPSTE24 is a small molecule inhibitor of the protein. Such inhibitors have been shown to be effective in reducing inflammation and pain in animal models of multiple sclerosis and chronic pain. One such inhibitor is a peptide that is derived from a region of the myelin sheath and has been shown to be effective in reducing the symptoms of multiple sclerosis and chronic pain in animal models of the disorders.

In conclusion, ZMPSTE24 is a protein that is involved in the development and maintenance of the myelin sheath and has been shown to be involved in the development and progression of multiple sclerosis and chronic pain. As a result, ZMPSTE24 is a potential drug target for these disorders and may be a valuable tool in the development of new treatments for these conditions. Further research is needed to fully understand the role of ZMPSTE24 in the development and maintenance of multiple sclerosis and chronic pain, as well as to determine the most effective drug treatments for these conditions.

Protein Name: Zinc Metallopeptidase STE24

Functions: Transmembrane metalloprotease whose catalytic activity is critical for processing lamin A/LMNA on the inner nuclear membrane and clearing clogged translocons on the endoplasmic reticulum (PubMed:33315887, PubMed:33293369). Proteolytically removes the C-terminal three residues of farnesylated proteins (PubMed:33315887, PubMed:33293369). Plays also an antiviral role independently of its protease activity by restricting enveloped RNA and DNA viruses, including influenza A, Zika, Ebola, Sindbis, vesicular stomatitis, cowpox, and vaccinia (PubMed:28246125, PubMed:28169297). Mechanistically, controls IFITM antiviral pathway to hinder viruses from breaching the endosomal barrier by modulating membrane fluidity (PubMed:35283811)

The "ZMPSTE24 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZMPSTE24 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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