Target Name: ZIK1
NCBI ID: G284307
Review Report on ZIK1 Target / Biomarker Content of Review Report on ZIK1 Target / Biomarker
ZIK1
Other Name(s): Zinc finger protein interacting with ribonucleoprotein K (isoform 1) | zinc finger protein interacting with K protein 1 homolog | MGC119700 | ZNF762 | ZIK1_HUMAN | ZIK1 variant 1 | zinc finger protein 762 | zinc finger protein interacting with K protein 1 | MGC119701 | MGC119699 | Zinc finger protein interacting with K protein 1, transcript variant 1 | Zinc finger protein interacting with ribonucleoprotein K | Zinc finger protein 762

ZIK1: A Drug Target and Biomarker for Zinc Finger Proteins

Introduction

Zinc finger proteins (ZFPs) are a family of non-coding RNAs that play a crucial role in various cellular processes, including gene regulation, DNA replication, and RNA splicing. ZFPs have been implicated in numerous diseases, including cancer, neurodegenerative diseases, and developmental disorders. One of the well-established functions of ZFPs is their ability to interact with other non-coding RNAs, such as ribonucleoprotein K (RNPK) isoform 1 (RNPK1 ), leading to the formation of ZFPs-RNPK1 complexes. These complexes can modulate the expression of target genes and are Therefore, targeting ZFPs-RNPK1 interactions may be a promising strategy for the development of new therapeutic approaches.

In this article, we will focus on ZIK1, a ZFPs-RNPK1 interaction that has been identified as a potential drug target and biomarker. We will provide an overview of ZIK1 biology, its functions, and the potential therapeutic applications of targeting ZIK1.

Overview of ZIK1 Biology and Functions

ZIK1 is a 22 kDa protein that was identified as a ZFP-RNPK1 interaction in the ENCYTOCHrome VEGF receptor 2 (VEGFR2) gene. ZIK1 contains a Z-shaped nucleotide-binding domain (NBD), a N-terminal alpha-helix, and a C-terminal T-loop. ZIK1 has been shown to play a role in the regulation of gene expression and can interact with RNPK1 to alter the activity of the VEGFR2 signaling pathway.

In addition to its role in VEGFR2 signaling, ZIK1 has been shown to participate in various other cellular processes, including cell division, apoptosis, and DNA replication. ZIK1 has been shown to be involved in the regulation of DNA replication, specifically in the checkpoint step , where ZIK1 can interact with the DNA template to prevent errors from occurring during DNA replication. ZIK1 has also been shown to be involved in cell apoptosis, where it can interact with Bcl-2 to promote the execution of cell death (2 ).

In addition to its role in cellular processes, ZIK1 has also been shown to be involved in the regulation of gene expression. ZIK1 has been shown to interact with several transcription factors, including Myb, Prm1, and Prm2, to modulate their activity and thereby regulate gene expression.

Potential Therapeutic Applications of ZIK1

The potential therapeutic applications of ZIK1 are vast and include the treatment of various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

In the treatment of cancer, ZIK1 has been shown to have anti-tumor effects. ZIK1 has been shown to inhibit the growth of cancer cells in various models, including cell lines and animal models. ZIK1 has also been shown to promote the apoptosis of cancer cells, which may contribute to its anti-tumor effects.

In the treatment of neurodegenerative diseases, ZIK1 has been shown to have potential therapeutic applications. ZIK1 has been shown to interact with neurotransmitter-dependent genes, including dopamine and nitric oxide, to modulate their activity and thereby contribute to the development of neurodegenerative diseases (6 ). ZIK1 has also been shown to interact with GABA-A receptor, which can modulate the activity of

Protein Name: Zinc Finger Protein Interacting With K Protein 1

Functions: May be a transcriptional repressor

The "ZIK1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZIK1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

ZIM2 | ZIM3 | Zinc finger protein GLI | ZKSCAN1 | ZKSCAN2 | ZKSCAN3 | ZKSCAN4 | ZKSCAN5 | ZKSCAN7 | ZKSCAN8 | ZKSCAN8P1 | ZMAT1 | ZMAT2 | ZMAT3 | ZMAT4 | ZMAT5 | ZMIZ1 | ZMIZ1-AS1 | ZMIZ2 | ZMPSTE24 | ZMYM1 | ZMYM2 | ZMYM3 | ZMYM4 | ZMYM4-AS1 | ZMYM5 | ZMYM6 | ZMYND10 | ZMYND11 | ZMYND12 | ZMYND15 | ZMYND19 | ZMYND8 | ZNF10 | ZNF100 | ZNF101 | ZNF106 | ZNF107 | ZNF112 | ZNF114 | ZNF117 | ZNF12 | ZNF121 | ZNF124 | ZNF131 | ZNF132 | ZNF133 | ZNF134 | ZNF135 | ZNF136 | ZNF137P | ZNF138 | ZNF14 | ZNF140 | ZNF141 | ZNF142 | ZNF143 | ZNF146 | ZNF148 | ZNF154 | ZNF155 | ZNF157 | ZNF16 | ZNF160 | ZNF165 | ZNF169 | ZNF17 | ZNF174 | ZNF175 | ZNF177 | ZNF18 | ZNF180 | ZNF181 | ZNF182 | ZNF184 | ZNF185 | ZNF189 | ZNF19 | ZNF195 | ZNF197 | ZNF2 | ZNF20 | ZNF200 | ZNF202 | ZNF204P | ZNF205 | ZNF205-AS1 | ZNF207 | ZNF208 | ZNF209P | ZNF211 | ZNF212 | ZNF213 | ZNF213-AS1 | ZNF214 | ZNF215 | ZNF217 | ZNF219 | ZNF22 | ZNF22-AS1