Target Name: ZFYVE28
NCBI ID: G57732
Review Report on ZFYVE28 Target / Biomarker Content of Review Report on ZFYVE28 Target / Biomarker
ZFYVE28
Other Name(s): Zinc finger FYVE domain containing 28 protein | hLst2 | Lateral signaling target protein 2 homolog (isoform 1) | Lateral signaling target protein 2 homolog | OTTHUMP00000217959 | OTTHUMP00000217955 | OTTHUMP00000217956 | Zinc finger FYVE-type containing 28, transcript variant 1 | zinc finger FYVE-type containing 28 | OTTHUMP00000217954 | zinc finger, FYVE domain containing 28 | MGC61592 | zinc finger FYVE domain-containing protein 28 | LST2 | Zinc finger FYVE domain-containing protein 28 | MGC43699 | KIAA1643 | OTTHUMP00000217958 | LST2_HUMAN | LYST2 | lateral signaling target-2 homolog | lst-2 | ZFYVE28 variant 1 | OTTHUMP00000217960

ZFYVE28: A Potential Drug Target and Biomarker

Zinc finger FYVE domains are a family of proteins that play a crucial role in various cellular processes. These domains are characterized by the presence of a zinc finger motif, which consists of a nucleotide-binding oligomerization (NBO) domain and a characteristic Zn2+-dependent conformational change. ZFYVE28, a protein that contains a ZFYVE28 domain, has been identified as a potential drug target and biomarker.

The ZFYVE28 protein

ZFYVE28 is a 28-kDa protein that is expressed in various tissues, including muscle, heart, brain, and cancer cells. It is localized to the endoplasmic reticulum (ER) and is predominantly expressed in the cytoplasm. ZFYVE28 is a member of the Zinc finger FYVE family, which includes several similar proteins, such as FYVE1, FYVE2, and FYVE3.

The ZFYVE28 domain

The ZFYVE28 domain is a specific type of FYVE domain that is characterized by the presence of a nucleotide-binding oligomerization (NBO) domain and a characteristic Zn2+-dependent conformational change. The NBO domain is a unique feature that allows for the specific binding of nucleotides to the protein. In ZFYVE28, the NBO domain is responsible for the binding of short oligonucleotides, such as tRNA, which are involved in protein synthesis.

The ZFYVE28 domain has been shown to play a critical role in various cellular processes, including cell signaling, DNA replication, and gene expression. ZFYVE28 has been shown to interact with several protein partners, including the transcription factor, p53. These interactions may contribute to the regulation of gene expression and the modulation of cellular processes.

Potential drug targets

The ZFYVE28 domain has been identified as a potential drug target due to its involvement in various cellular processes. Several studies have shown that modulation of ZFYVE28 activity can lead to the inhibition of cellular processes, such as cell growth, angiogenesis, and cancer progression. This suggests that targeting ZFYVE28 may be an effective way to treat various diseases.

In addition to its involvement in cellular processes, ZFYVE28 has also been shown to be a biomarker for several diseases, including cancer. The ZFYVE28 gene has been shown to be highly expressed in various cancer types, including breast, ovarian, and colorectal cancer. This suggests that targeting ZFYVE28 may be an effective way to diagnose and treat these cancers.

Biomarker potential

The ZFYVE28 domain has been shown to be a biomarker for several diseases, including cancer. The ZFYVE28 gene has been shown to be highly expressed in various cancer types, including breast, ovarian, and colorectal cancer. This suggests that targeting ZFYVE28 may be an effective way to diagnose and treat these cancers.

In addition to its potential as a drug target, ZFYVE28 has also been shown to be a potential biomarker for several other diseases. For example, ZFYVE28 has been shown to be highly expressed in the brains of individuals with Alzheimer's disease, which may indicate that targeting ZFYVE28 may be an effective way to treat this debilitating disease.

Conclusion

In conclusion, ZFYVE28 is a protein that contains a ZFYVE28 domain, which is a unique feature that allows for the specific binding of nucleotides to the protein. The ZFYVE28 domain has been shown to play a critical role in various cellular processes, including cell signaling, DNA replication, and gene expression. The ZFYVE28 domain has also been identified as a potential drug target and biomarker for several diseases, including cancer. Targeting

Protein Name: Zinc Finger FYVE-type Containing 28

Functions: Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated

The "ZFYVE28 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZFYVE28 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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