Target Name: ZFP36L1
NCBI ID: G677
Review Report on ZFP36L1 Target / Biomarker Content of Review Report on ZFP36L1 Target / Biomarker
ZFP36L1
Other Name(s): MRNA decay activator protein ZFP36L1 (isoform 2) | Protein TIS11B | ZFP36 ring finger protein like 1, transcript variant 1 | zinc finger protein 36, C3H1 type-like 1 | Zinc finger protein 36, C3H1 type-like 1 | ERF1 | EGF-response factor 1 | zinc finger protein, C3H type, 36-like 1 | Zinc finger protein, C3H type, 36-like | ZFP36 ring finger protein like 1, transcript variant 3 | mRNA decay activator protein ZFP36L1 | Early response factor Berg36 | MRNA decay activator protein ZFP36L1 (isoform 1) | butyrate response factor 1 | ZFP36 ring finger protein like 1 | cMG1 | Berg36 | zinc finger protein 36, C3H type-like 1 | Butyrate response factor 1 | TPA-induced sequence 11b | ERF-1 | BRF1 | early response factor Berg36 | ZFP36-like 1 | ZFP36L1 variant 1 | TISB_HUMAN | TIS11B | ZFP36L1 variant 3 | RNF162B

ZFP36L1: A promising drug target and biomarker for cancer treatment

Abstract:

ZFP36L1, an isoform of the microRNA-containing gene ZFP36L1, has been identified as a promising drug target and biomarker for cancer treatment. This protein plays a crucial role in the regulation of cell growth, apoptosis, and angiogenesis, and has been implicated in various diseases, including cancer. In this article, we will discuss the biology of ZFP36L1, its functions in cancer, and its potential as a drug target and biomarker.

Introduction:

ZFP36L1 is a 21-kDa protein that is expressed in various tissues and cells of the body. It is a member of the ZFP gene family, which is known for the production of small non-coding RNAs, including microRNAs (miRNAs). ZFP36L1 is widely expressed in various tissues of the body and has been implicated in various biological processes, including cell growth, apoptosis, and angiogenesis.

In cancer, ZFP36L1 has been shown to play a crucial role in the regulation of cell growth, apoptosis, and angiogenesis. It has been shown to be involved in the development and progression of various cancers, including breast, ovarian, and colorectal cancers. ZFP36L1 has also been shown to be involved in the regulation of cell apoptosis, which is a critical process in cancer progression and treatment.

As a drug target, ZFP36L1 has been identified as a potential target for cancer treatment. By inhibiting the activity of ZFP36L1, it is possible to reduce the growth and survival of cancer cells. This has been shown in various studies, including cell-based assays and animal models of cancer.

In addition to its potential as a drug target, ZFP36L1 has also been shown to be a potential biomarker for cancer. Its expression has been shown to be associated with the development and progression of various cancers, including breast, ovarian, and colorectal cancers. This suggests that ZFP36L1 may be a useful biomarker for cancer diagnosis and treatment.

The biology of ZFP36L1:

ZFP36L1 is a 21-kDa protein that is expressed in various tissues and cells of the body. It is a member of the ZFP gene family, which is known for the production of small non-coding RNAs, including microRNAs (miRNAs). ZFP36L1 is widely expressed in various tissues of the body, including brain, heart, liver, and muscle.

ZFP36L1 plays a crucial role in the regulation of cell growth, apoptosis, and angiogenesis. It is involved in the regulation of cell proliferation, and has been shown to play a role in the regulation of cell apoptosis. ZFP36L1 has been shown to be involved in the regulation of angiogenesis, which is the process by which new blood vessels are formed in the body.

In cancer, ZFP36L1 has been shown to play a crucial role in the regulation of cell growth, apoptosis, and angiogenesis. It has been shown to be involved in the development and progression of various cancers, including breast, ovarian, and colorectal cancers. ZFP36L1 has also been shown to be involved in the regulation of cell apoptosis, which is a critical process in cancer progression and treatment.

Molecular mechanisms of ZFP36L1:

ZFP36L1 is a 21-kDa protein that is expressed in various tissues and cells of the body. It is a member of the ZFP gene family, which is known for the production of small non-coding RNAs, including microRNAs (miRNAs). ZFP36L1 is widely expressed in various tissues of the body, including brain, heart, liver, and muscle.

The molecular mechanisms of ZFP36L1 are not well understood. However, it is known that ZFP36L1 plays a crucial role in the regulation of cell growth, apoptosis, and angiogenesis. It is involved in the regulation of cell proliferation, and has been shown to play a role in the regulation of cell apoptosis. ZFP36L1 has also been shown to be involved in the regulation of angiogenesis,

Protein Name: ZFP36 Ring Finger Protein Like 1

Functions: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity)

The "ZFP36L1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZFP36L1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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