SELL: Key Protein in ECM and Signaling Pathways (G6402)

Target Name: SELL

NCBI ID: G6402

SELL

SELL: Key Protein in ECM and Signaling Pathways

SELL (soluble L-selectin) is a protein that is expressed in various tissues throughout the body, including the skin, hair, and connective tissues. It is a key component of the extracellular matrix (ECM), which is a complex tissue matrix that is responsible for providing support, structure, and mechanical properties to various tissues. SELL is one of the most well-known proteins that are involved in the ECM, and it is widely studied for its role in various physiological processes.

SELL is a transmembrane protein that is composed of a unique disulfide-rich region and a cytoplasmic tail. It is expressed in a variety of tissues, including the skin, hair, nails, and various connective tissues such as tendons, ligaments, and intercellular junctions. SELL is also expressed in the blood vessels, where it plays a role in the regulation of blood vessel permeability and vascular remodeling.

One of the key functions of SELL is its role in cell-cell adhesion. SELL is involved in the formation of tight junctions, which are specialized junctions that are responsible for ensuring the proper alignment of cells that make up tissues. tight junctions are critical for various physiological processes, including cell signaling, and they are also involved in the regulation of ion and solute transport.

SELL is also involved in the regulation of cell migration and the maintenance of tissue homeostasis. It is able to interact with a variety of different signaling pathways, including TGF-β, Wnt, and Hedgehog. These signaling pathways are responsible for regulating cell growth, differentiation, and movement, as well as the regulation of cell survival and inflammation.

SELL is also involved in the regulation of the immune response. It is a key player in the development of immune tolerance, as well as the regulation of inflammation. SELL has been shown to play a role in the regulation of dendritic cell function, and it has been shown to be involved in the regulation of T-cell receptor signaling.

In addition to its role in cell-cell adhesion, SELL is also involved in the regulation of various signaling pathways that are involved in inflammation and immune responses. It is able to interact with a variety of different signaling pathways, including TGF-β, Wnt, and Hedgehog. These signaling pathways are responsible for regulating cell growth, differentiation, and movement, as well as the regulation of cell survival and inflammation.

SELL is also involved in the regulation of the development and maintenance of tissues. It plays a role in the regulation of cell proliferation, and it is involved in the development of various tissues, including the nervous system and the endocrine system.

SELL is also involved in the regulation of the regulation of cell death. It is able to interact with a variety of different signaling pathways, including TGF-β, Wnt, and Hedgehog. These signaling pathways are responsible for regulating cell growth, differentiation, and movement, as well as the regulation of cell survival and inflammation.

In conclusion, SELL is a protein that is widely studied for its role in various physiological processes. It is involved in the regulation of cell-cell adhesion, cell migration, and the immune response, as well as the regulation of tissue homeostasis, development and maintenance. SELL is also involved in the regulation of cell death and has been shown to play a key role in the development of immune tolerance. Given its involvement in these various processes, SELL is a potential drug target and a biomarker for a variety of diseases.

Protein Name: Selectin L

Functions: Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641). Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641)

The "SELL Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SELL comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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