FBXW4: A Potential Drug Target and Biomarker (G6468)

Target Name: FBXW4

NCBI ID: G6468

FBXW4

FBXW4: A Potential Drug Target and Biomarker

FBXW4, also known as F-box and WD-40 domain-containing protein 4, is a protein that plays a crucial role in various cellular processes. FBXW4 is a 21-kDa protein that is highly conserved in various species, including humans. It is composed of 251 amino acid residues and has a pI of 5.9. FBXW4 is localized to the endoplasmic reticulum (ER) and is involved in the regulation of various cellular processes, including cell adhesion, migration, and signaling pathways.

Disease and Therapeutic Potential

FBXW4 has been implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. FBXW4 has been shown to be involved in the regulation of cellular processes that are crucial for disease progression, such as cell division, migration, and angiogenesis.

In cancer, FBXW4 has been shown to promote the growth and survival of various cancer cell types. For example, studies have shown that FBXW4 can promote the growth of breast cancer cells and that it can also inhibit the production of anti-cancer drugs.

In neurodegenerative diseases, FBXW4 has been shown to contribute to the progression of neurodegeneration. For example, studies have shown that FBXW4 can cause neurotoxicity in rat models of Alzheimer's disease and that it can also contribute to the development of Parkinson's disease.

In autoimmune disorders, FBXW4 has been shown to play a role in the regulation of immune cell function. For example, studies have shown that FBXW4 can regulate the production of antibodies in mouse models of autoimmune disorders.

Therapeutic Potential

FBXW4 has the potential to be a drug target for various diseases due to its involvement in various cellular processes that are crucial for disease progression. Because of its conserved nature and its involvement in various diseases, FBXW4 has the potential to be a valuable drug target for cancer, neurodegenerative diseases, and autoimmune disorders.

In cancer, FBXW4 can be a potential drug target due to its role in cell division and its ability to promote the growth and survival of cancer cells. For example, researchers have shown that inhibiting FBXW4 can cause a significant reduction in the growth and survival of cancer cells. Additionally, studies have shown that targeting FBXW4 with small molecules has the potential to be an effective therapy for various cancers.

In neurodegenerative diseases, FBXW4 can be a potential drug target due to its role in the regulation of cellular processes that are crucial for disease progression. For example, researchers have shown that modulating FBXW4 activity can cause a reversal of neurodegeneration in animal models of Alzheimer's disease and Parkinson's disease. Additionally, studies have shown that targeting FBXW4 with small molecules has the potential to be an effective therapy for neurodegenerative diseases.

In autoimmune disorders, FBXW4 can be a potential drug target due to its role in the regulation of immune cell function. For example, researchers have shown that modulating FBXW4 activity can cause a reduction in the production of antibodies in animal models of autoimmune disorders. Additionally, studies have shown that targeting FBXW4 with small molecules has the potential to be an effective therapy for autoimmune disorders.

Conclusion

FBXW4 is a protein that plays a crucial role in various cellular processes and has been implicated in various diseases. FBXW4 has the potential to be a drug target for cancer, neurodegenerative diseases, and autoimmune disorders due to its involvement in

Protein Name: F-box And WD Repeat Domain Containing 4

Functions: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling

The "FBXW4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FBXW4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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