HS3ST6: A Key Enzyme in The Glycosylation Pathway (G64711)

Target Name: HS3ST6

NCBI ID: G64711

HS3ST6

HS3ST6: A Key Enzyme in The Glycosylation Pathway

Heparan sulfate-glucosamine 3-sulfotransferase 6 (HS3ST6) is a protein that is expressed in a variety of tissues throughout the body, including the liver, spleen, and pancreas. It is a key enzyme in the glycosylation pathway, which is a process that involves the addition of sugar (glucose) to proteins. This process is important for the structure, stability, and function of proteins, and is involved in many cellular processes, including cellular signaling, inflammation, and infection.

HS3ST6 is a 21 kDa protein that is composed of 216 amino acids. It has a molecular weight of 29,112 Da and a calculated pI of 6.9. It is expressed in a variety of tissues, including the liver, spleen, and pancreas, and is found in both the cytoplasm and the endoplasmic reticulum.

HS3ST6 is involved in the glycosylation pathway at multiple levels. It is the rate-limiting step in the first step of the pathway, which involves the addition of a glucose molecule to a specific amino acid residue. It is also involved in the second step of the pathway, which involves the addition of a second glucose molecule to the same amino acid residue.

HS3ST6 is a good candidate for drug targeting because of its involvement in the glycosylation pathway. The addition of glucose molecules to proteins is a critical step in many cellular processes, and is often involved in the regulation of cellular signaling, inflammation, and infection. Therefore , drugs that are able to interfere with this process could be effective in treating a variety of diseases.

In addition to its involvement in the glycosylation pathway, HS3ST6 is also a potential biomarker for certain diseases. The glycosylation pathway is a complex process that is involved in the regulation of many cellular processes, including cellular signaling, inflammation, and infection. Therefore, changes in the levels of HS3ST6 in certain tissues or cells could be an indication of certain diseases. For example, decreased levels of HS3ST6 in the liver could be an indication of liver disease, and decreased levels of HS3ST6 in the endoplasmic reticulum could be an indication of neurodegenerative diseases.

Overall, HS3ST6 is a protein that is involved in the glycosylation pathway and has been identified as a potential drug target and biomarker for a variety of diseases. Further research is needed to fully understand its role in cellular processes and its potential as a drug.

Protein Name: Heparan Sulfate-glucosamine 3-sulfotransferase 6

Functions: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes Simplex Virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate

The "HS3ST6 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HS3ST6 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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