GINS3: A Potential Drug Target and Biomarker for DNA Replication

Target Name: GINS3

NCBI ID: G64785

GINS3

GINS3: A Potential Drug Target and Biomarker for DNA Replication

Introduction

GINS3 (GINS protein PSF3, ISOFORM A) is a key component of the DNA replication complex, which is responsible for ensuring the accuracy and fidelity of DNA replication. GINS3 plays a crucial role in the proper functioning of the replication complex by participating in the checkpoint system, which ensures that the two copies of the double helix are identical and that any errors in replication are detected and corrected.

GINS3 functions as a protein that contains two domains: an N-terminal domain that contains a nucleotide-binding oligomerization domain (NBO), and a C-terminal domain that contains a protrusion domain and a nucleotide-binding oligomerization domain (NBO). The NBO is responsible for interacting with DNA template, while the CBO domain interacts with the replication complex proteins, including the checkpoint protein SIRT1.

GINS3 is a well-conserved protein that is highly conserved in various organisms, including bacteria, archaea, and eukaryotes. It is expressed in various cell types, including eukaryotic cells, and is involved in various cellular processes, including DNA replication, transcription, and DNA damage repair.

GINS3 as a Drug Target

GINS3 has been identified as a potential drug target due to its involvement in various cellular processes that are associated with various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. GINS3 has been shown to be involved in various cellular processes that are associated with the development and progression of these diseases, including:

1. DNA replication and errors: GINS3 is involved in the proper functioning of the DNA replication complex, which is responsible for ensuring the accuracy and fidelity of DNA replication. Studies have shown that GINS3 is involved in the checkpoint system, which ensures that the two copies of the double helix are identical and that any errors in replication are detected and corrected. Therefore, targeting GINS3 may be a promising approach for treating diseases that are associated with DNA replication errors, such as cancer.
2. Cellular stress: GINS3 has been shown to be involved in cellular stress responses, including the stress caused by DNA damage. DNA damage can occur due to various factors, including replication errors, UV radiation, and radiation therapy. Therefore, targeting GINS3 may be a promising approach for treating diseases that are associated with cellular stress, such as cancer.
3. Neurodegenerative diseases: GINS3 has been shown to be involved in the development and progression of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. These diseases are characterized by the progressive loss of brain cells, and the proper functioning of the DNA replication complex is essential for the prevention and treatment of these diseases. Therefore, targeting GINS3 may be a promising approach for treating neurodegenerative diseases.

GINS3 as a Biomarker

GINS3 has also been shown to be involved in various cellular processes that are associated with the development and progression of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Therefore, GINS3 may be a useful biomarker for the diagnosis and monitoring of these diseases.

One of the main advantages of GINS3 as a biomarker is its expression in various cell types, including cancer cells, which makes it a suitable candidate for targeting with small molecules or antibodies. GINS3 has been shown to be involved in various cellular processes that are associated with the development and progression of cancer, including the regulation of cell growth, apoptosis, and angiogenesis. Therefore, targeting GINS3 with small molecules or antibodies may be a promising approach for treating

Protein Name: GINS Complex Subunit 3

Functions: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653, PubMed:28414293). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232)

The "GINS3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GINS3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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