SLC1A2: Glucose Metabolism and Intercellular Communication Protein

Target Name: SLC1A2

NCBI ID: G6506

SLC1A2

SLC1A2: Glucose Metabolism and Intercellular Communication Protein

SLC1A2 (Sodium-Glucose cotransporter 1A2) is a protein that is expressed in most tissues in the body. It is a member of the SLC family of transmembrane proteins, which are known for their ability to transport various substances across cell membranes. One of the Unique features of SLC1A2 are its role in glucose metabolism, as it is the primary transmembrane protein for glucose transport in the body.

SLC1A2 is a 22kDa protein that is expressed in most tissues in the body, including the brain, heart, liver, and kidneys. It is primarily localized to the endoplasmic reticulum (ER), which is the protein synthesis and modification site for most proteins in the cell. SLC1A2 is also expressed in the plasma membrane (PM) and is thought to play a role in the regulation of ion and water transport.

One of the unique features of SLC1A2 is its role in glucose metabolism. As the primary transmembrane protein for glucose transport, SLC1A2 is involved in the uptake and release of glucose from the bloodstream into the cell. Glucose is the body's main energy substance, so , SLC1A2 plays a key role in glucose metabolism. Glucose enters cells through the SLC1A2 protein on the cell membrane, and then enters the cells for various metabolic reactions. Within cells, glucose can be utilized through various pathways, such as cellular respiration, fatty acid synthesis, and protein synthesis. The glucose transport function of SLC1A2 is subject to multiple regulations, including gene expression, protein post-modification, and intracellular transport mechanisms.

In addition, SLC1A2 is also involved in intercellular communication. In neurons, SLC1A2 can interact with receptors on the neuronal membrane, thereby affecting neuronal excitatory transmission. In the liver, SLC1A2 binds to transcription factors related to glucose regulation, thereby participating in the homeostasis regulation of glucose metabolism and liver homeostasis.

SLC1A2 is also a potential drug target. Studies have shown that SLC1A2 is expressed in a variety of tumors and is closely related to the metabolism and viability of tumor cells. Therefore, drug research targeting SLC1A2 is of great significance for the treatment of tumors. At present, some drug studies have made some progress in the anti-tumor effect of SLC1A2, but these studies have not been fully confirmed.

In addition to being a drug target, SLC1A2 may also be an important biomarker. The expression level of SLC1A2 can reflect the status of glucose metabolism and therefore can be used as a biomarker to evaluate glucose metabolism disorders such as diabetes. In addition, SLC1A2 can also be used as a molecular indicator to study intercellular communication and cellular metabolic activities.

In summary, SLC1A2 is a protein that plays an important role in glucose metabolism and intercellular communication. By studying the molecular mechanisms and biological functions of SLC1A2, the process of glucose metabolism and disease development can be better understood. With the continuous advancement of technology, SLC1A2 has great research value and application prospects as a drug target or biomarker.

Protein Name: Solute Carrier Family 1 Member 2

Functions: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:14506254, PubMed:15265858, PubMed:26690923). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity)

The "SLC1A2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLC1A2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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