SLC22A12: A Carrier Protein for The Blood-Brain Barrier (G116085)

Target Name: SLC22A12

NCBI ID: G116085

SLC22A12

SLC22A12: A Carrier Protein for The Blood-Brain Barrier

SLC22A12 is a member of the Absolute Carrier Family 22 and is located on chromosome 12. It is a gene that encodes a protein known as SLC22A12, which is a carrier protein of various neurological disorders. The SLC22A12 protein is involved in the transport of various substances, including drugs, across the blood-brain barrier and is a potential drug target for various neurological disorders.

SLC22A12 is a transmembrane protein that is expressed in various tissues and organs, including the brain. It is involved in the transport of various substances across the blood-brain barrier, including drugs that are used to treat neurological disorders. The blood-brain barrier is a specialized barrier that separates the brain from the blood and helps to protect it from harmful substances. However, this barrier is not always selective and can allow drugs to enter the brain, which can cause potential side effects.

SLC22A12 is a carrier protein that is involved in the transport of various substances across the blood-brain barrier. It is a key protein in the regulation of drug transport across the barrier and is a potential drug target for various neurological disorders.

One of the main functions of SLC22A12 is its role in the transport of drugs that are used to treat neurological disorders. Many drugs that are used to treat conditions such as Alzheimer's disease, Parkinson's disease, and schizophrenia work by modulating the activity of SLC22A12. By blocking the activity of SLC22A12, these drugs can increase or decrease the amount of the drug that enters the brain, which can improve the effectiveness of the treatment.

Another function of SLC22A12 is its role in the regulation of ion transport in the brain. Ions are essential for the normal functioning of the brain and play a key role in the regulation of various physiological processes, including muscle and nerve function. SLC22A12 is involved in the regulation of the movement of ions across the blood-brain barrier, which is important for the control of ion homeostasis in the brain.

SLC22A12 is also involved in the regulation of the transport of various waste products from the brain to the bloodstream. These waste products include neurotransmitters, which are the chemical messengers that are used to communicate between neurons, as well as other substances that are generated during cellular metabolism. SLC22A12 is involved in the transport of these waste products across the blood-brain barrier, which is important for the proper disposal of waste products and the maintenance of cellular homeostasis.

In conclusion, SLC22A12 is a carrier protein that is involved in the transport of various substances across the blood-brain barrier. Its function as a carrier protein makes it a potential drug target for various neurological disorders. The regulation of drug transport across the barrier by SLC22A12 is a complex process that is influenced by various factors, including the type and concentration of the drug, the properties of the blood-brain barrier, and the activity of other proteins involved in the barrier. Further research is needed to fully understand the role of SLC22A12 in the regulation of drug transport across the blood-brain barrier and its potential as a drug target for neurological disorders.

Protein Name: Solute Carrier Family 22 Member 12

Functions: Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions (PubMed:12024214, PubMed:22194875, PubMed:35144162, PubMed:35462902). Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid (PubMed:12024214, PubMed:22194875). Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-) (PubMed:12024214). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate (PubMed:12024214). Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption (PubMed:21350910). Orotate transport is Cl(-)-dependent (PubMed:21350910)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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