SLC25A44 in Tesirine Transport and Heart Ion Channels, Drug Target Or Biomarker for Neurological Disorders

Target Name: SLC25A44

NCBI ID: G9673

SLC25A44

SLC25A44 in Tesirine Transport and Heart Ion Channels, Drug Target Or Biomarker for Neurological Disorders

SLC25A44 (FLJ90431) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and liver. It is a member of the sulfate transport family 25, which is a diverse family of proteins that play a critical role in the transport of a variety of molecules across cell membranes. One of the unique aspects of SLC25A44 is its ability to transport the drug tesirine, which is used to treat neurological diseases such as Parkinson's disease and Alzheimer's disease.

SLC25A44 is a 21-kDa protein that is expressed in the brain, heart, and liver. It is characterized by its ability to transport tesirine across cell membranes. In tesirine-treated cells, SLC25A44 is expressed at a level of 10-50% of its normal level. This increase in expression is important for the transport of tesirine across the cell membrane and into the cell.

SLC25A44 has also been shown to play a role in the regulation of ion channels in the heart. It has been shown to block the activation of the voltage-gated sodium channels (VGSA) in the heart, which are responsible for the rapid depolarization that occurs during the initiation of an action potential. This blockade of VGSA channels can have a positive effect on the heart's electrical activity, which may be important for the treatment of certain cardiovascular diseases.

In addition to its role in the regulation of ion channels, SLC25A44 has also been shown to play a role in the development and progression of certain neurological diseases. For example, it has been shown to be expressed in the brains of individuals with Alzheimer's disease, and it has been shown to be involved in the regulation of the neurotransmitter dopamine.

SLC25A44 is also a potential biomarker for certain neurological diseases. For example, it has been shown to be elevated in the brains of individuals with Parkinson's disease, and it has been shown to be involved in the development and progression of certain neurological disorders.

In conclusion, SLC25A44 is a protein that is expressed in various tissues throughout the body and plays a critical role in the transport of tesirine across cell membranes. It has also been shown to play a role in the regulation of ion channels in the heart and in the development and progression of certain neurological diseases. As a result, SLC25A44 may be a valuable drug target or biomarker for the treatment of these and other neurological disorders.

Protein Name: Solute Carrier Family 25 Member 44

Functions: Mitochondrial solute transporter which transports branched-chain amino acid (BCAA; valine, leucine and isoleucine) into mitochondria in brown adipose tissue (BAT) (By similarity). BAT is involved in BCAA catabolism and actively utilizes BCAA in the mitochondria for thermogenesis (PubMed:31435015)

The "SLC25A44 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLC25A44 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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