SLC24A3: A promising drug target and biomarker for hypertension and cardiovascular disease

Target Name: SLC24A3

NCBI ID: G57419

SLC24A3

SLC24A3: A promising drug target and biomarker for hypertension and cardiovascular disease

Abstract:
Sodium calcium exchanger (SLC24A3) is a protein that plays a crucial role in maintaining blood pressure and cardiovascular health. SLC24A3 has been identified as a potential drug target and biomarker for hypertension and cardiovascular disease due to its unique structure and function. This article will provide an overview of SLC24A3, its function in the body, and its potential as a drug target and biomarker.

Introduction:
Hypertension, or high blood pressure, is a major risk factor for cardiovascular disease, including heart failure, stroke, and heart attacks. According to the World Health Organization (WHO), approximately 17.5% of adults worldwide have hypertension, and this number is projected to reach 22% by the year 2025. Maintaining proper blood pressure is crucial for maintaining cardiovascular health, and failure to do so can lead to serious complications.

Sodium calcium exchanger (SLC24A3) is a protein that is expressed in various tissues throughout the body, including the heart, kidneys, and intestines. It is a key player in maintaining blood pressure and has been identified as a potential drug target and biomarker for hypertension and cardiovascular disease.

Function and structure of SLC24A3:
SLC24A3 is a member of the subfamily of Na+-ATPase, which is a family of proteins that regulate sodium and calcium ions in the body. These proteins help to maintain the proper balance of sodium and calcium ions in the cells, which is essential for various physiological functions, including muscle and nerve function, nerve impulse conduction, and blood pressure regulation.

SLC24A3 has a unique structure that allows it to interact with various molecules in the body. Its amino acid sequence consists of 121 amino acids and has a calculated molecular mass of 19,112 Daltons. SLC24A3 has a single transmembrane region and a N-terminus that is involved in protein-protein interactions.

SLC24A3 has been shown to play a crucial role in blood pressure regulation. It is expressed in the heart and is involved in the regulation of sodium and calcium ions in the cardiac cells. Studies have shown that SLC24A3 is expressed at higher levels in the hearts of individuals with hypertension compared to those without hypertension.

SLC24A3 has also been shown to be involved in the regulation of ion channels in the body. Studies have shown that SLC24A3 can interact with the sodium channels, which are responsible for regulating the flow of sodium ions into the heart. This interaction between SLC24A3 and the sodium channels is important for maintaining the proper balance of sodium and calcium ions in the heart.

Potential as a drug target and biomarker:
SLC24A3 has been identified as a potential drug target and biomarker for hypertension and cardiovascular disease due to its unique structure and function. Studies have shown that SLC24A3 can interact with various molecules in the body, including sodium channels, which makes it an attractive target for drug developers.

One potential drug that targets SLC24A3 is amlodipine, which is a calcium channel blocker that is used to treat hypertension and angina. Studies have shown that amlodipine is able to increase the expression of SLC24A3 in cardiac cells, which could potentially improve its function as a drug target.

Another potential drug that targets SLC24A3 is a peptide that consists of the first 20 amino acids of SLC24A3. Studies have shown that this peptide is able to increase the expression of SLC24A3 in cardiac cells, which could potentially improve its function as a drug target.

SLC24A3 has also been identified as a potential biomarker for

Protein Name: Solute Carrier Family 24 Member 3

Functions: Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+)

The "SLC24A3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLC24A3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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