SLC24A1: A Potential Drug Target and Biomarker for Retinal Rod Na+/Ca+/K+ Exchanger

Target Name: SLC24A1

NCBI ID: G9187

SLC24A1

SLC24A1: A Potential Drug Target and Biomarker for Retinal Rod Na+/Ca+/K+ Exchanger

Abstract:

SLC24A1, a member of the selective transport protein (SLC) family, is expressed in the retina and plays a crucial role in maintaining Na+/Ca2+/K+ homeostasis. Imbalances in these ion channels can lead to various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. SLC24A1 has been identified as a potential drug target and biomarker for these disorders. This article will summarize the current understanding of SLC24A1 and its potential implications as a drug target and biomarker.

Introduction:

Sodium channels are essential for maintaining the resting membrane potential of neurons and are involved in various physiological processes, including neuronal communication and generation of action potentials. The sodium channels are also known as action potential channels because they play a crucial role in generating the electrical signals that are responsible for transmitting information from the brain to the rest of the body.

SLC24A1 is a member of the selective transport protein (SLC) family, which includes proteins that transport a wide variety of molecules across cell membranes. SLC24A1 is primarily expressed in the retina and is involved in maintaining Na+/Ca2+/K+ homeostasis, which is essential for maintaining the structure and function of the retina.

Disease-related changes in ion channels have been implicated in various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Imbalances in Na+/Ca2+/K+ channels can lead to increased neurotoxicity and an increased risk of disease progression.

SLC24A1 as a drug target:

SLC24A1 has been identified as a potential drug target for these disorders due to its involvement in Na+/Ca2+/K+ homeostasis. Alterations in the levels of Na+/Ca2+/K+ channels can contribute to the development and progression of neurodegenerative diseases.

SLC24A1 has been shown to regulate the activity of various ion channels, including Na+, Ca2+, and K+ channels. SLC24A1 has been shown to play a role in the regulation of neuronal excitability and in the modulation of pain perception.

SLC24A1 has also been shown to be involved in the regulation of the production of reactive oxygen species (ROS), which can contribute to the development of neurodegenerative diseases.

SLC24A1 as a biomarker:

SLC24A1 has also been identified as a potential biomarker for neurodegenerative diseases due to its expression and its role in maintaining homeostasis. The levels of SLC24A1 have been shown to be altered in various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

SLC24A1 has been shown to be involved in the regulation of Na+/Ca2+/K+ channels, which are critical for maintaining the structure and function of the retina. Imbalances in these channels have been implicated in the development and progression of various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

Conclusion:

SLC24A1 is a member of the selective transport protein (SLC) family and is expressed in the retina. It plays a crucial role in maintaining Na+/Ca2+/K+ homeostasis and has been identified as a potential drug target and biomarker for neurodegenerative diseases. Further research is needed to fully understand the role of SLC24A1 in maintaining brain health and the potential implications of targeting this protein

Protein Name: Solute Carrier Family 24 Member 1

Functions: Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed:26631410). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness (PubMed:20850105). Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation (PubMed:20850105)

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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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