SLC22A11: A Gene Involved in Various Physiological Processes and Potential Drug Targets

Target Name: SLC22A11

NCBI ID: G55867

SLC22A11

SLC22A11: A Gene Involved in Various Physiological Processes and Potential Drug Targets

SLC22A11 is a gene that encodes a protein known as solute carrier family 22 member 11. The SLC22A11 protein is a transmembrane protein that is expressed in various tissues and organs throughout the body. It plays a critical role in the transport of solutes, including ions and small molecules, across cell membranes.

SLC22A11 is a gene that has been implicated in a number of physiological processes in the body. One of its well-established functions is its role in the regulation of electrolyte balance. Specifically, SLC22A11 is involved in the transport of sodium and potassium ions across cell membranes, which is essential for maintaining the resting membrane potential of cells and for maintaining the integrity of the nervous system.

In addition to its role in electrolyte balance, SLC22A11 is also involved in the regulation of pH homeostasis, as well as the transport of other molecules across cell membranes. It has been shown to play a critical role in the regulation of various physiological processes, including blood pressure, heart rate, and inflammation.

SLC22A11 is also a potential drug target for several diseases. For example, SLC22A11 has been shown to be involved in the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Additionally, SLC22A11 has been implicated in the development of several types of cancer, including breast and ovarian cancer.

SLC22A11 is also a potential biomarker for several diseases, including neurodegenerative diseases and cancer. For example, SLC22A11 has been shown to be abnormally expressed in the brains of individuals with Alzheimer's disease, and it has also been shown to be involved in the development of cancer.

In conclusion, SLC22A11 is a gene that encodes a protein that plays a critical role in the regulation of various physiological processes in the body. It is a potential drug target and biomarker for several diseases, including neurodegenerative diseases and cancer. Further research is needed to fully understand the role of SLC22A11 in these processes and to develop effective treatments.

Protein Name: Solute Carrier Family 22 Member 11

Functions: Antiporter that mediates the transport of conjugated steroids and other specific organic anions at the basal membrane of syncytiotrophoblast and at the apical membrane of proximal tubule epithelial cells, in exchange for anionic compounds (PubMed:10660625, PubMed:11907186, PubMed:15291761, PubMed:15037815, PubMed:15102942, PubMed:15576633, PubMed:17229912, PubMed:18501590, PubMed:26277985, PubMed:28027879). May be responsible for placental absorption of fetal-derived steroid sulfates such as estrone sulfate (E1S) and the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S), as well as clearing waste products and xenobiotics from the fetus (PubMed:12409283). Maybe also be involved in placental urate homeostasis (PubMed:17229912). Facilitates the renal reabsorption of organic anions such as urate and derived steroid sulfates (PubMed:15037815, PubMed:17229912). Organic anion glutarate acts as conteranion for E1S renal uptake (PubMed:15037815, PubMed:17229912). Possible transport mode may also include DHEA-S/E1S exchange (PubMed:28027879). Also interacts with inorganic anions such as chloride and hydroxyl ions, therefore possible transport modes may include E1S/Cl(-), E1S/OH(-), urate/Cl(-) and urate/OH(-) (PubMed:17229912). Also mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may be involved in their renal excretion (PubMed:11907186). Also able to uptake anionic drugs, diuretics, bile salts and ochratoxin A (PubMed:10660625, PubMed:26277985). Mediates the unidirectional efflux of glutamate and aspartate (PubMed:28027879). Glutamate efflux down its transmembrane gradient may drive SLC22A11/OAT4-mediated placental uptake of E1S (PubMed:26277985)

The "SLC22A11 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLC22A11 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets