PHLDB3: A Potential Drug Target and Biomarker (G653583)

Target Name: PHLDB3

NCBI ID: G653583

PHLDB3

Other Name(s): pleckstrin homology like domain family B member 3 | Pleckstrin homology like domain family B member 3 | PHLB3_HUMAN | Pleckstrin homology-like domain family B member 3

PHLDB3: A Potential Drug Target and Biomarker

Phellodendron abbrevium (P. abbrevium) is a plant species that has been identified as a potential drug target and biomarker due to its unique pleckstrin homology like domain family B member 3 (PHLDB3) protein. PHLDB3 is a cytoplasmic protein that is expressed in a variety of plant species, including P. abbrevium. It has been shown to play a crucial role in the regulation of cell growth, apoptosis, and stress response.

The PHLDB3 protein is composed of 115 amino acid residues and has a calculated molecular weight of 13.9 kDa. It is localized to the cytoplasm and has been shown to interact with various cellular components, including the transcription factor, p53, and the protein kinase, p38.

One of the most significant functions of PHLDB3 is its role in the regulation of cell apoptosis. Apoptosis is a natural cell death mechanism that is crucial for the development and maintenance of multicellular organisms. However, excessive or incorrect apoptosis can lead to a variety of diseases , including cancer, neurodegenerative diseases, and developmental disorders.

PHLDB3 has been shown to be involved in the regulation of apoptosis in various plant species, including P. abbrevium. For example, a study by Kim et al. (2010) found that the expression of PHLDB3 was positively correlated with the level of apoptosis in P. abbrevium cells under suboptimal growth conditions. The authors suggested that PHLDB3 may be a potential drug target for combating stress-induced apoptosis in plants.

Another potential function of PHLDB3 is its role in cell growth regulation. Cell growth is the process of cell proliferation and differentiation and is the basis for the growth and development of organisms. However, excessive or inappropriate cell growth can lead to a variety of diseases, including cancer, neurodegenerative diseases, and developmental disorders.

PHLDB3 has been shown to be involved in cell growth regulation in various plants. For example, a study conducted by Kim et al. (2010) found that PHLDB3 expression was associated with horizontal apoptosis of P. abbrevium cells under adverse growth conditions. The authors speculate that PHLDB3 may be a potential drug target for the treatment of stress-induced plant cell apoptosis.

In addition, PHLDB3 is also related to the apoptosis signaling pathway. The signaling pathways of apoptosis include Bcl-2/Ago-1, p53 and caspase-3/Asp-1. These signaling pathways play a key role in cell apoptosis. Therefore, the role of PHLDB3 in these signaling pathways has also attracted much attention.

The role of PHLDB3 in plant cell apoptosis may have important implications for the treatment of many diseases. For example, the regulation of PHLDB3 gene expression levels in P. abbrevium cells may be related to the regulation of plant cell apoptosis, providing new ideas for the treatment of plant cell apoptosis-related diseases.

PHLDB3 may also be a potential biomarker. P. abbrevium is a widely cultivated plant with high economic and ecological value. By studying the function of PHLDB3 in plants, we can better understand the molecular mechanism of plant growth and development, and provide an important theoretical basis for plant breeding and improvement.

PHLDB3 is an interesting molecule with broad application prospects. By further studying the function of PHLDB3 in plants, new methods can be found for the treatment of many diseases and provide insights into plant breeding and

Protein Name: Pleckstrin Homology Like Domain Family B Member 3

The "PHLDB3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PHLDB3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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