SMARCD3: A Potential Drug Target for Neurodegenerative Diseases

Target Name: SMARCD3

NCBI ID: G6604

SMARCD3

SMARCD3: A Potential Drug Target for Neurodegenerative Diseases

SMARCD3 (SMARCD3 variant 3) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the SMAR family of proteins, which are known for their role in intracellular signaling. In particular, SMARCD3 is involved in the regulation of mitochondrial function and has been implicated in a number of cellular processes, including the development and progression of neurodegenerative diseases.

SMARCD3 has been identified as a potential drug target in the field of neurodegenerative diseases, due to its involvement in the regulation of cellular processes that are disrupted in these conditions. For example, SMARCD3 has been shown to play a role in the development of neurofibrillary tangles, which are a hallmark of Alzheimer's disease, and has been shown to be involved in the regulation of neurogenesis, the process by which new neurons are generated in the brain.

In addition to its role in neurodegenerative diseases, SMARCD3 has also been shown to be involved in a number of other cellular processes that are important for overall cellular health. For example, it is involved in the regulation of cell death, which is important for the maintenance of tissue homeostasis and for the regulation of cellular processes that are necessary for growth and development. In addition, SMARCD3 is involved in the regulation of cell signaling, which is important for the regulation of a wide range of cellular processes and is involved in the development and progression of many diseases.

SMARCD3 has also been shown to be involved in the regulation of mitochondrial function, which is important for the production of energy in the cell and is involved in the development and progression of many neurodegenerative diseases. For example, SMARCD3 has been shown to play a role in the regulation of mitochondrial dynamics and has been shown to be involved in the production of reactive oxygen species (ROS), which are highly reactive molecules that can damage cellular components and contribute to the development of neurodegenerative diseases.

In addition to its role in neurodegenerative diseases, SMARCD3 has also been shown to be involved in a number of other cellular processes that are important for overall cellular health. For example, it is involved in the regulation of cell signaling, which is important for the regulation of a wide range of cellular processes and is involved in the development and progression of many diseases. In addition, SMARCD3 is involved in the regulation of cell death, which is important for the maintenance of tissue homeostasis and for the regulation of cellular processes that are necessary for growth and development.

SMARCD3 is a protein that has been shown to play a role in a wide range of cellular processes and is involved in the development and progression of many neurodegenerative diseases. As a result, it is a potential drug target for the treatment of these conditions. Further research is needed to fully understand the role of SMARCD3 in cellular processes and to determine the most effective way to target this protein in order to treat neurodegenerative diseases.

Protein Name: SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily D, Member 3

Functions: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity)

The "SMARCD3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SMARCD3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets