POLR3D: A Potential Drug Target and Biomarker for DNA-Directed RNA Polymorphism

Target Name: POLR3D

NCBI ID: G661

POLR3D

POLR3D: A Potential Drug Target and Biomarker for DNA-Directed RNA Polymorphism

Introduction

DNA-directed RNA polymerase III (RNA polymerase III, RNA-P III) is a key enzyme in the human genome that plays a critical role in the regulation of gene expression. RNA-P III is required for the transcription of expression exons into RNA. Participation. RNA-P III not only plays a key role in the regulation of gene expression, but also plays an important role in repairing DNA damage, genetic diagnosis and cancer treatment.

POLR3D is a ribonuclease III (RNA polymerase III subunit), also known as DNA-guided RNA polymerase III. POLR3D plays a key role in the regulation of gene expression by RNA-P III. By binding to the DNA template, POLR3D is able to recognize and cut the DNA strand at a specific position, providing a suitable promoter for the initiation of RNA-P III. In addition, POLR3D is also involved in the substrate binding and product release of RNA-P III, thereby playing an important role in the regulation of gene expression of RNA-P III.

The gene coding region of POLR3D is located on human chromosome U17 and is a gene with a length of 1,900 nucleotides. The protein encoded by the POLR3D gene consists of four tissue-differentiation domains (TSS), including: P1, P2, P3 and P4. P1 is located at the N-terminal of the POLR3D gene, P2 and P3 are located at the C-terminal of the POLR3D gene, and P4 is located in the center of the POLR3D gene.

Protein structure of POLR3D

The protein structure of POLR3D is composed of four domains P1-P4. The P1 domain is a short 伪-helix located at the N-terminus of POLR3D. The P2 and P3 domains are located at the C-terminus of POLR3D, and they are composed of a long 伪-helix and a 尾-sheet. The P4 domain is located in the center of POLR3D, which is a large 尾-body.

POLR3D activity

The activity of POLR3D is closely related to its protein structure. The activity of POLR3D depends on the integrity of its protein structure. The protein structure of POLR3D is composed of four domains, therefore, disrupting any domain of POLR3D may affect its activity.

Drug targets for POLR3D

POLR3D is a potential drug target because inhibiting POLR3D activity may help treat a variety of diseases. First, POLR3D plays an important role in cancer treatment. POLR3D is expressed in a variety of cancers, including lung cancer, breast cancer, colon cancer, and ovarian cancer. Studies have shown that the expression level of POLR3D is negatively correlated with the survival rate of cancer patients. Therefore, inhibiting the activity of POLR3D may be an effective cancer treatment.

In addition, POLR3D is also associated with a variety of autoimmune diseases. POLR3D is highly expressed in autoimmune diseases, including rheumatoid arthritis, lupus erythematosus, and scleroderma. Therefore, inhibiting the activity of POLR3D may be an effective treatment for autoimmune diseases.

Biomarkers for POLR3D

POLR3D is a gene of great value in biomedical research. Due to the important role of POLR3D in cancer treatment and autoimmune diseases, studying biomarkers of POLR3D has important clinical significance for the study of cancer treatment and autoimmune diseases.

Studying biomarkers for POLR3D could help doctors better understand the progression of the disease and the effectiveness of treatments. POLR3D biomarkers can be used to assess disease severity, predict disease progression, and evaluate treatment effectiveness. In addition, studying biomarkers of POLR3D can also provide researchers with clues to study the molecular mechanism of POLR3D.

Conclusion

POLR3D is an enzyme that plays an important role in DNA-guided RNA transcription. The activity of POLR3D depends on the integrity of its protein structure. Inhibiting the activity of POLR3D may help treat a variety of diseases, including cancer and autoimmune diseases. Therefore, POLR3D is an important drug target and an important object for studying DNA guide RNA transcription.

Protein Name: RNA Polymerase III Subunit D

Functions: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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