Target Name: TERF1
NCBI ID: G7013
Review Report on TERF1 Target / Biomarker Content of Review Report on TERF1 Target / Biomarker
TERF1
Other Name(s): PIN2 | TERF1 variant 2 | Telomeric repeat-binding factor 1 | TERF1_HUMAN | TTAGGG repeat-binding factor 1 | FLJ41416 | TRBF1 | TERF1 variant 1 | Telomeric repeat-binding factor 1 (isoform 2) | telomeric protein Pin2/TRF1 | TRF | Telomeric repeat binding protein 1 | t-TRF1 | TRF1 | Telomeric repeat binding factor 1, transcript variant 1 | telomeric repeat binding factor 1 | Telomeric repeat binding factor 1, transcript variant 2 | hTRF1-AS | Telomeric repeat-binding factor 1 (isoform 1) | Telomeric repeat binding factor 1 | telomeric repeat binding factor (NIMA-interacting) 1 | NIMA-interacting protein 2 | Telomeric protein Pin2/TRF1

TERF1: A Potential Drug Target for Various Diseases

TERF1 (PIN2) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the PIN family of transmembrane proteins, which are known for their role in intracellular signaling. One of the key functions of TERF1 is its role in the regulation of ion channels, which are responsible for the flow of electrical signals through cells.

Recent studies have identified TERF1 as a potential drug target for various diseases, including epilepsy, heart failure, and kidney disease. This is because TERF1 is involved in the regulation of ion channels in these conditions, and alterations in ion channel function have been linked to the development of these diseases.

In addition to its role in ion channel regulation, TERF1 has also been shown to play a role in the regulation of cell signaling pathways. For example, TERF1 has been shown to be involved in the regulation of the protein kinase kinase (PKC) pathway, which is a well-established pathway involved in a wide range of cellular processes, including cell signaling, cell division, and inflammation.

The PKC pathway is a highly conserved protein-protein interaction pathway that is involved in the regulation of many cellular processes, including cell signaling, DNA replication, and cell adhesion. The role of TERF1 in this pathway suggests that it may be a useful target for the development of drugs that target signaling pathways involved in a variety of diseases.

In conclusion, TERF1 is a protein that is expressed in various tissues throughout the body and is involved in the regulation of ion channels and cell signaling pathways. Its potential as a drug target makes it an attractive target for the development of new treatments for a variety of diseases. Further research is needed to fully understand the role of TERF1 in disease and to develop effective treatments.

Protein Name: Telomeric Repeat Binding Factor 1

Functions: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways

The "TERF1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TERF1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

TERF1P3 | TERF2 | TERF2IP | TERLR1 | TERT | TES | TESC | TESK1 | TESK2 | TESMIN | TESPA1 | TET1 | TET2 | TET2-AS1 | TET3 | Tetraspanin | TEX10 | TEX101 | TEX11 | TEX12 | TEX13A | TEX13B | TEX13C | TEX14 | TEX15 | TEX19 | TEX2 | TEX21P | TEX22 | TEX26 | TEX261 | TEX264 | TEX28 | TEX29 | TEX30 | TEX33 | TEX35 | TEX36 | TEX36-AS1 | TEX37 | TEX38 | TEX41 | TEX43 | TEX44 | TEX45 | TEX46 | TEX47 | TEX48 | TEX49 | TEX50 | TEX52 | TEX53 | TEX55 | TEX56P | TEX9 | TF | TFAM | TFAMP1 | TFAP2A | TFAP2A-AS1 | TFAP2A-AS2 | TFAP2B | TFAP2C | TFAP2D | TFAP2E | TFAP4 | TFB1M | TFB2M | TFCP2 | TFCP2L1 | TFDP1 | TFDP1P2 | TFDP2 | TFDP3 | TFE3 | TFEB | TFEC | TFF1 | TFF2 | TFF3 | TFG | TFIID Basal Transcription Factor Complex | TFIIIC2 complex | TFIP11 | TFIP11-DT | TFPI | TFPI2 | TFPT | TFR2 | TFRC | TG | TGDS | TGFA | TGFA-IT1 | TGFB1 | TGFB1I1 | TGFB2 | TGFB2-AS1 | TGFB3 | TGFBI