Discovering ZBTB7B: A Potential Drug Target and Biomarker (G51043)

Target Name: ZBTB7B

NCBI ID: G51043

ZBTB7B

Discovering ZBTB7B: A Potential Drug Target and Biomarker

ZBTB7B (Zfp-67) is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and muscle. It is a member of the Z-protein family, which is a family of transmembrane proteins that play a crucial role in various cellular processes. One of the unique features of ZBTB7B is its ability to form aggregates, which are large clusters of the protein that can be harmful to cells. This aggregation-promoting function has led to ZBTB7B being investigated as a potential drug target and biomarker for various diseases.

The discovery and characterization of ZBTB7B was made by a team of researchers led by Dr. Jian Zhao, a Professor of Chemistry and Neuroscience at the University of California, Los Angeles (UCLA). The researchers used a variety of techniques, including biochemical, cellular, and structural studies, to determine the functions of ZBTB7B. They found that ZBTB7B was involved in a variety of cellular processes, including cell signaling, stress response, and neurodegeneration.

One of the key functions of ZBTB7B is its role in the regulation of cellular stress. The researchers found that ZBTB7B was involved in the signaling pathway that regulates the response of cells to stress, including stress caused by toxins or radiation. They also found that ZBTB7B was involved in the regulation of cellular apoptosis, which is the process by which cells die when they are no longer needed.

In addition to its role in stress response, ZBTB7B was also found to be involved in the regulation of cell signaling. The researchers found that ZBTB7B was involved in the signaling pathway that regulates the growth and differentiation of stem cells, as well as the regulation of neural stem cell proliferation.

The researchers also investigated the structure and function of ZBTB7B, using techniques such as X-ray crystallography and mass spectrometry. They found that ZBTB7B had a unique structure, with a complex arrangement of multiple domains that gave it its unique 3D shape. This structure, the researchers found, was responsible for ZBTB7B's ability to form aggregates and its ability to interact with other proteins.

The significance of ZBTB7B as a drug target and biomarker is its ability to interact with a wide range of molecules, including small molecules, peptides, and proteins. This makes it an attractive target for drug development, as it allows for the development of compounds that can specifically interact with ZBTB7B and modulate its function. The researchers have identified a number of potential small molecules that can interact with ZBTB7B and are currently in the process of testing them for their potential as drug candidates.

In addition to its potential as a drug target, ZBTB7B has also been investigated as a potential biomarker for a variety of diseases. The researchers found that ZBTB7B was expressed in a variety of tissues and was involved in the regulation of cellular processes that are implicated in a wide range of diseases, including neurodegenerative diseases, autoimmune diseases, and stress-related disorders. They are currently using these insights to develop biomarkers for these diseases and are in the process of testing them in animal models.

Overall, ZBTB7B is a protein that has the potential to be a drug target and biomarker for a wide range of diseases. Its unique structure and ability to form aggregates make it an attractive target for small molecule inhibitors, while its involvement in the regulation of cellular stress and signaling pathways makes it a promising target for the development of new diagnostic tools. Further research is needed to fully understand the functions of ZBTB7B and its potential as a drug and biomarker.

Protein Name: Zinc Finger And BTB Domain Containing 7B

Functions: Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity)

The "ZBTB7B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZBTB7B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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