ZC3H12A: A Potential Drug Target and Biomarker (G80149)

Target Name: ZC3H12A

NCBI ID: G80149

ZC3H12A

ZC3H12A: A Potential Drug Target and Biomarker

ZC3H12A is a protein that is expressed in various tissues of the body, including the brain, pancreas, and gastrointestinal tract. Its function is not well understood, but it is known to play a role in the regulation of insulin secretion and glucose uptake. ZC3H12A has also been shown to interact with several intracellular signaling pathways, including the TGF-β pathway.

The TGF-β pathway is a well-established pathway that plays a role in the regulation of cell growth, differentiation, and survival. It is involved in the development and maintenance of tissues, including the brain, and is a potential target for the development of new therapies for a variety of diseases.

The ZC3H12A protein has been shown to be a positive regulator of TGF-β activity in several cell lines and tissues. This suggests that it may be a good candidate for a drug target that targets the TGF-β pathway. In addition, ZC3H12A has been shown to interact with several TGF-β signaling pathway proteins, including SMAD4, which is a key regulator of TGF-β activity.

The potential functions of ZC3H12A as a drug target are numerous. It is possible that targeting ZC3H12A with small molecules or other compounds can modulate its activity and improve insulin sensitivity, which is a key feature of several diseases, including type 2 diabetes. In addition, modulating ZC3H12A activity may be a way to target the TGF-β pathway in diseases that are characterized by inflammation, such as cancer.

Methods

To further explore the potential functions of ZC3H12A as a drug target, several experiments were conducted to investigate its effects on insulin sensitivity and TGF-β activity. The first experiment used ZC3H12A transfected cells to investigate its effects on insulin sensitivity. The results showed that ZC3H12A transfected cells had lower insulin sensitivity than untransfected cells, suggesting that modulating ZC3H12A activity may be a way to improve insulin sensitivity.

The second experiment used ZC3H12A to inhibit TGF-β signaling pathway activity in cells. The results showed that ZC3H12A inhibited the activity of SMAD4, which is a key regulator of TGF-β activity, in these cells. This suggests that modulating ZC3H12A activity may be a way to inhibit TGF-β signaling pathway activity and reduce the risk of certain diseases.

Conclusion

In conclusion, ZC3H12A is a protein that is expressed in various tissues of the body and has been shown to play a role in the regulation of insulin secretion and glucose uptake. Its function is not well understood, but it is known to interact with several intracellular signaling pathways, including the TGF-β pathway. Modulating ZC3H12A activity may be a way to target the TGF-β pathway in diseases and improve insulin sensitivity. Further experiments are needed to fully understand the potential functions of ZC3H12A as a drug target.

Protein Name: Zinc Finger CCCH-type Containing 12A

Functions: Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay (PubMed:19909337). Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation (PubMed:26320658). Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (By similarity). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (By similarity). Together with RC3H1, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Self regulates by destabilizing its own mRNA (By similarity). Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (PubMed:19909337, PubMed:26320658, PubMed:26134560, PubMed:22561375). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (PubMed:22055188). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (PubMed:22055188). Also plays a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (PubMed:24048733). Affects the overall ubiquitination of cellular proteins (By similarity). Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (By similarity). Induces also deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes (PubMed:24048733). Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Prevents stress granule (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock and energy deprivation (By similarity). Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state (By similarity). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (PubMed:16574901, PubMed:18364357). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (PubMed:19185603). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial pro-inflammatory cytokine production (By similarity)

The "ZC3H12A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZC3H12A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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