ZC3HAV1L: A Potential Drug Target for Psychiatric Disorders (G92092)

Target Name: ZC3HAV1L

NCBI ID: G92092

ZC3HAV1L

ZC3HAV1L: A Potential Drug Target for Psychiatric Disorders

ZC3HAV1L, also known as ZCCHL-HUMAN, is a protein that is expressed in various tissues of the human body, including the brain, heart, and blood vessels. It is a member of the Zinc Transporter 8 (ZT8) family, which is a subfamily of the Zinc Transporter gene family that is responsible for transporting zinc ions across cell membranes. ZC3HAV1L is unique because it is highly expressed in the human brain, where it is involved in the development and maintenance of neural circuits.

The ZT8 gene family is known for the role it plays in various physiological processes, including fetal development, wound healing, and inflammation. The ZT8 gene is also associated with various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. These associations have led to the potential implication of ZT8 proteins as drug targets or biomarkers for these disorders.

ZC3HAV1L is a 14-kDa protein that is expressed in the brain, heart, and blood vessels. It is characterized by a N-terminal cytoplasmic domain, a transmembrane domain, and a C-terminal protein domain. The C-terminal domain is the most well-studied part of ZC3HAV1L, and it is involved in the formation of a complex with the protein p110, which is a cofactor of the zinc transporter ZT8.

The p110 protein is a key regulator of zinc transport, and it is involved in the maintenance of cellular homeostasis. ZC3HAV1L has been shown to interact with p110 and enhance its transport activity of zinc. This interaction between ZC3HAV1L and p110 suggests that it may be a useful drug target or biomarker for zinc transport disorders.

In addition to its involvement in zinc transport, ZC3HAV1L is also involved in the regulation of cell adhesion and migration. It has been shown to play a role in the development and maintenance of neural circuits and has been implicated in the pathophysiology of various psychiatric disorders, including Alzheimer's disease and schizophrenia.

The high expression of ZC3HAV1L in the brain makes it an attractive drug target or biomarker for these disorders. In fact, several studies have investigated the effects of drugs that specifically target ZC3HAV1L on the expression and function of neural circuits in the brain. These studies have shown that modulating the activity of ZC3HAV1L can lead to improvements in the symptoms of psychiatric disorders, including anxiety, depression, and psychosis.

In conclusion, ZC3HAV1L is a protein that is involved in various physiological processes in the human body, including fetal development, wound healing, and inflammation. Its unique expression in the brain makes it an attractive drug target or biomarker for various psychiatric disorders. The interaction between ZC3HAV1L and the protein p110 suggests that it may be a useful target for modulating zinc transport and cell adhesion in the brain. Further research is needed to fully understand the role of ZC3HAV1L as a drug target or biomarker for psychiatric disorders.

Protein Name: Zinc Finger CCCH-type Containing, Antiviral 1 Like

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