Target Name: ZNF189
NCBI ID: G7743
Review Report on ZNF189 Target / Biomarker Content of Review Report on ZNF189 Target / Biomarker
ZNF189
Other Name(s): zinc finger protein 189 | Zinc finger protein 189, transcript variant 1 | Zinc finger protein 189 | Zinc finger protein 189 (isoform 1) | ZNF189 variant 1 | ZN189_HUMAN

ZNF189: A Potential Drug Target and Biomarker forfungal Infections

Zinc finger proteins (ZFPs) are a family of transmembrane proteins that play a crucial role in various cellular processes. One of the ZFPs, ZNF189, has been identified as a potential drug target and biomarker for fungal infections. In this article, we will explore the biology of ZNF189 and its potential as a drug target and biomarker for fungal infections.

The ZNF189 Protein

ZNF189 is a 21-kDa protein that is expressed in various tissues, including liver, spleen, lung, and brain. It is a nuclear protein and is localized to the cytoplasm. ZNF189 has a unique structure that consists of a catalytic domain, a transmembrane region, and an intracellular region.

The ZNF189 gene

The ZNF189 gene is located on chromosome 6p21. It encodes a protein that has been shown to play a role in various cellular processes, including cell signaling, DNA replication, and stress response. ZNF189 has also been shown to be involved in the regulation of inflammation and cellular apoptosis.

Expression of ZNF189

ZNF189 is expressed in various tissues and cells, including the liver, spleen, lung, and brain. It is typically expressed at levels of 1-10% of the total cell protein in these tissues. ZNF189 has been shown to be involved in various cellular processes, including cell signaling, DNA replication, and stress response.

Drug Targeting ZNF189

ZNF189 has been shown to be a potential drug target for fungal infections. Fungal infections are a common pathogen that can cause a variety of health problems, including athlete's foot, candidiasis, and aspergillosis. These infections are caused by overgrowth of fungi, which can disrupt the balance of the immune system and cause an immune response.

One of the challenges in treating fungal infections is the development of resistance to drugs, which can make the treatment more difficult. ZNF189 has been shown to be involved in the regulation of drug sensitivity in various fungal infections. By targeting ZNF189, researchers may be able to develop more effective treatments for fungal infections.

Biomarker Potential

ZNF189 has also been shown to be a potential biomarker for fungal infections. The detection and quantification of ZNF189 in body fluids, such as blood or urine, can be used to monitor the severity and duration of fungal infections. This may be particularly useful in the treatment of aspergillosis, a serious fungal infection that can be life-threatening if left untreated.

Conclusion

In conclusion, ZNF189 is a protein that has been shown to play a role in various cellular processes, including cell signaling, DNA replication, and stress response. It has also been identified as a potential drug target for fungal infections. The detection and quantification of ZNF189 in body fluids may be a useful biomarker for the treatment of fungal infections. Further research is needed to fully understand the role of ZNF189 in these processes and to develop more effective treatments for fungal infections.

Protein Name: Zinc Finger Protein 189

Functions: May be involved in transcriptional regulation

The "ZNF189 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF189 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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