OR4C5: A Potential Drug Target and Biomarker for Membrane Receptors
OR4C5: A Potential Drug Target and Biomarker for Membrane Receptors
Membrane receptors are essential proteins that play a crucial role in cellular signaling. They are involved in various physiological processes, including sensory perception, neurotransmission, and hormone signaling. Among the many membrane receptors, the seven transmembrane helix (TM) receptors are a subfamily that have unique functions and are of interest for drug development and research. OR4C5 is one of these TM receptors, and it is a potential drug target and biomarker.
OR4C5 is a seven transmembrane helix receptor that is expressed in various tissues, including brain, heart, liver, and pancreas. It is a G protein-coupled receptor (GPCR), which means that it uses the energy-consuming GPCR signaling pathway to transmit signals from the cell surface to the inside of the cell. The OR4C5 receptor is composed of a transmembrane domain, a cytoplasmic domain, and an extracellular loop.
OR4C5 Receptor Signaling
OR4C5 is involved in various signaling pathways, including sensory perception, neurotransmission, and hormone signaling. One of the most well-studied functions of OR4C5 is its role in pain perception. OR4C5 is known to be involved in the transmission of pain signals from the skin to the brain. When the skin is stimulated with a hot or cold temperature, OR4C5 is activated, leading to the sensation of pain.
OR4C5 is also involved in neurotransmission, specifically in the transmission of glutamatergic neurotransmission. Glutamatergic neurotransmission is the release of glutamate, a neurotransmitter that is involved in learning and memory. The OR4C5 receptor is known to play a role in the regulation of glutamatergic neurotransmission, and it is thought to be involved in the modulation of pain sensitivity.
OR4C5 Receptor Inhibition
OR4C5 has also been shown to be involved in the regulation of inflammation. Inflammation is a critical response of the immune system to harmful substances in the body. The OR4C5 receptor is involved in the regulation of inflammation by suppressing the release of pro-inflammatory cytokines, such as TNF-伪 and IL-1尾.
OR4C5 is also involved in the regulation of cell survival. Pro-inflammatory cytokines have been shown to promote cell death, but the OR4C5 receptor is involved in the regulation of cell survival by suppressing the release of pro-apoptotic cytokines, such as PD-1 . PD-1 is a transmembrane protein that is involved in cancer cell survival, and it is thought to be involved in the regulation of OR4C5 signaling.
OR4C5 as a Drug Target
OR4C5 is a potential drug target due to its involvement in various signaling pathways. Drugs that can inhibit OR4C5 signaling have been shown to have therapeutic potential for various diseases, including pain, neurodegenerative diseases, and cancer.
One of the most promising drugs that may target OR4C5 is a small molecule called U-8719, which is a selective inhibitor of OR4C5. U-8719 has been shown to be effective in animal models of pain, neurodegenerative diseases, and cancer.
Another drug that may target OR4C5 is a monoclonal antibody called AC-145, which is designed to block the interaction between OR4C5 and its ligand. AC-145 has been shown to be effective in preclinical studies for pain and neurodegenerative diseases.
OR4C5 as a Biomarker
OR4C5 may also be used as a biomarker for various diseases. For example, OR4C5 is
Protein Name: Olfactory Receptor Family 4 Subfamily C Member 5
Functions: Odorant receptor
The "OR4C5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about OR4C5 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
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