CAMK2A: A Potential Drug Target for Various Diseases (G815)

Target Name: CAMK2A

NCBI ID: G815

CAMK2A

CAMK2A: A Potential Drug Target for Various Diseases

CAMK2A (calcium-dependent equine kinase II subunit) is a protein that plays an important signal transduction role in cells. It plays a key role in a variety of physiological processes, including cell proliferation, differentiation, and apoptosis. At the same time, CAMK2A is also considered a risk factor and therapeutic target for many diseases. This article will introduce the structure, function, drug target properties of CAMK2A and its prospects in clinical application.

structure

CAMK2A consists of 199 amino acids and is a member of the tubulin family. Microtubules are a kind of cytoskeleton in the cytoplasm, a tubular structure with a diameter of about 20 nanometers formed by protein polymerization. CAMK2A is located in the protein tail of microtubules and is composed of two 伪-helices and two 尾-sheets. It functions as a signal transduction molecule within cells, so its structure is crucial to understanding its function.

Function

CAMK2A plays an important role in a variety of physiological processes, including cell proliferation, differentiation, and apoptosis. During cell proliferation, CAMK2A binds to tubulin and participates in spindle formation and stability. During cell differentiation, CAMK2A binds to tubulin and participates in cell cycle progression. During the process of cell apoptosis, CAMK2A participates in apoptotic signal transduction on the cell membrane.

CAMK2A is also involved in many important biological processes, including cell signal transduction, neuronal function, muscle contraction and cell adhesion. In these processes, CAMK2A plays a key regulatory role and can affect cell behavior and function.

Drug target properties

CAMK2A is a potential drug target because of its key role in various physiological processes. Many studies have shown that CAMK2A inhibitors can inhibit the growth and spread of cancer cells. CAMK2A inhibitors can also block apoptotic signal transduction in neurons, thereby improving neuronal function. During muscle contraction, CAMK2A inhibitors can inhibit the contraction of muscle cells, thereby reducing muscle pain and damage.

In clinical applications, CAMK2A inhibitors are widely used to treat a variety of diseases, including cancer, neurodegenerative diseases, and pain. For example, CAMK2A inhibitors such as gemcitabine (geVIP) have been used to treat ovarian and breast cancer. In addition, CAMK2A inhibitors can also be used to treat neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease.

in conclusion

CAMK2A is an important protein that plays an important signal transduction role in cells. CAMK2A inhibitors can inhibit the growth and spread of cancer cells, improve neuronal function, and reduce muscle pain and damage. In clinical applications, CAMK2A inhibitors are widely used to treat a variety of diseases, including cancer, neurodegenerative diseases, and pain. Future research can further study the structure and function of CAMK2A and develop more effective CAMK2A inhibitors, providing new ideas and methods for the treatment of various diseases.

Protein Name: Calcium/calmodulin Dependent Protein Kinase II Alpha

Functions: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity)

The "CAMK2A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CAMK2A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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