Caspase Recruitment Domain Family Member 11: A Promising Target for Neurodegenerative Disorders

Target Name: CARD11

NCBI ID: G84433

CARD11

Caspase Recruitment Domain Family Member 11: A Promising Target for Neurodegenerative Disorders

Caspase recruitment domain family member 11 (CARD11) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a key regulator of cell death and has been implicated in a number of diseases, including neurodegenerative disorders, cancer, and autoimmune diseases.

One of the unique features of CARD11 is its ability to interact with other proteins, including caspases. Caspases are a family of proteins that play a central role in cell death, and they are involved in the process of apoptosis, which is a natural and necessary part of cell growth and development. By interacting with caspases, CARD11 is able to regulate the activity of these proteins and influence the cell death that occurs in the body.

CARD11 is a member of the Caspase recruitment domain family, which is a group of proteins that are known for their ability to interact with caspases. This family includes several other proteins, including CARD10, CARD12, and CARD13. These proteins are involved in a variety of cellular processes, including cell death, cell signaling, and inflammation.

One of the key functions of CARD11 is its role in regulating cell death. In neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, cells are unable to properly die and continue to cause damage to the brain, leading to the progressive loss of brain cells and the development of the disease. CARD11 has been shown to play a role in this process by regulating the activity of caspases, which are involved in the process of cell death.

In addition to its role in cell death, CARD11 is also involved in the regulation of cell signaling. It has been shown to interact with a variety of signaling proteins, including T-cell receptor 4 (TCR4) and the protein p53. These interactions are involved in the regulation of cellular processes such as cell growth, differentiation, and inflammation.

CARD11 has also been shown to be involved in the regulation of inflammation. It has been shown to interact with the protein NF-kappa-B (nuclear factor kappa B), which is involved in the regulation of inflammation. This interaction between CARD11 and NF-kappa-B suggests that CARD11 may play a role in the regulation of inflammatory responses.

CARD11 has also been shown to be involved in a variety of other cellular processes, including cell adhesion, cell migration, and the regulation of ion channels. It has been shown to interact with a variety of proteins, including the protein E-cadherin, which is involved in cell adhesion, and the protein Na+/K+-ATPase, which is involved in the regulation of ion channels.

Despite its involvement in a wide range of cellular processes, CARD11 is not yet a well-studied protein. There are only a few studies that have investigated the role of CARD11 in neurodegenerative disorders, and more research is needed to fully understand its function and potential as a drug target.

In conclusion, Caspase recruitment domain family member 11 (CARD11) is a protein that is involved in a wide range of cellular processes, including cell death, cell signaling, and inflammation. Its unique ability to interact with caspases makes it a promising target for the development of new drugs for a variety of neurodegenerative disorders. Further research is needed to fully understand the function of CARD11 and its potential as a drug.

Protein Name: Caspase Recruitment Domain Family Member 11

Functions: Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308). Stimulates the phosphorylation of BCL10 (PubMed:11356195). Also activates the TORC1 signaling pathway (PubMed:28628108)

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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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