CAPN3: A Protein Regulating Cell Survival and Plurality (G825)

Target Name: CAPN3

NCBI ID: G825

CAPN3

CAPN3: A Protein Regulating Cell Survival and Plurality

CAPN3, or CANP 3, is a protein that is expressed in the brain and is known for its role in the regulation of cell survival and proliferation. It is a member of the cap non-coding RNA (ncRNA) family, which is characterized by the presence of a cis-regulated RNA response element (CRE) in the non-coding region of the gene. CAPN3 has been shown to play a role in the development and progression of several neurological disorders, including Alzheimer's disease and Parkinson's disease. As a As a result, CAPN3 has emerged as a promising drug target for the treatment of these disorders.

The CAPN3 protein is composed of 21 amino acid residues and has a calculated molecular weight of 19.9 kDa. It is expressed in a variety of tissues, including the brain, heart, and pancreas, and is primarily localized to the peri-synaptic region of nerves metacells. CAPN3 is known to play a role in the regulation of neuronal excitability and has been shown to play a role in the modulation of synaptic plasticity.

One of the most significant functions of CAPN3 is its ability to regulate the survival and proliferation of neuronal cells. Studies have shown that CAPN3 plays a role in the regulation of cell survival by preventing the programmed cell death that occurs following neuronal damage. This is achieved through the regulation of several cellular processes, including the regulation of cell apoptosis, the modulation of cell cycle progression, and the regulation of neurotrophin signaling.

In addition to its role in cell survival, CAPN3 is also known to play a role in the regulation of neuronal excitability. Studies have shown that CAPN3 modulates the levels of neurotransmitter release from neurons and that this modulation is critical for the regulation of neuronal excitability. This modulation is achieved through the regulation of several intracellular signaling pathways, including the regulation of neurotransmitter release by neurotrophins and the regulation of ion channels in neurons.

The CAPN3 protein is also known to play a role in the regulation of synaptic plasticity, which is the ability of the nervous system to change and adapt over time. Studies have shown that CAPN3 modulates the levels of neurotransmitter release from neurons and that this modulation is critical for the regulation of synaptic plasticity. This is achieved through the regulation of several intracellular signaling pathways, including the regulation of neurotransmitter release by neurotrophins and the regulation of ion channels in neurons.

In conclusion, CAPN3 is a protein that is known to play a critical role in the regulation of cell survival, proliferation, and synaptic plasticity. As a result, CAPN3 has emerged as a promising drug target for the treatment of neurological disorders, including Alzheimer's disease and Parkinson's disease. Further research is needed to fully understand the role of CAPN3 in these disorders and to develop effective treatments.

Protein Name: Calpain 3

Functions: Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-409'. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329)

The "CAPN3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CAPN3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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