CARD9: Regulating Cell Signaling, Death, Tissue Repair and Cellular Processes

Target Name: CARD9

NCBI ID: G64170

CARD9

CARD9: Regulating Cell Signaling, Death, Tissue Repair and Cellular Processes

CARD9, also known as Caspase recruitment domain-containing protein 9 (isoform 1), is a protein that plays a critical role in cell signaling pathways. It is a protein that is expressed in a variety of tissues, including the brain, heart, and immune system, and is involved in the regulation of cell death, cell proliferation, and tissue repair.

One of the key functions of CARD9 is its role in cell signaling pathways. It is a protein that is involved in the regulation of cell adhesion, a process that is critical for the formation and maintenance of tissues. CARD9 is also involved in the regulation of cell signaling pathways that are responsible for the regulation of cell growth, differentiation, and survival.

Another important function of CARD9 is its role in the regulation of cell death. CARD9 is involved in the regulation of cell death, which is a critical process that is essential for the development and maintenance of tissues. It is known that CARD9 plays a key role in the regulation of apoptosis, which is a process that is responsible for the programmed cell death that occurs in response to various stimuli, including stress, nutrient deprivation, and DNA damage.

In addition to its role in cell signaling pathways and cell death, CARD9 is also involved in the regulation of tissue repair. It is a protein that is involved in the regulation of the wound healing process, which is essential for the formation and maintenance of tissues. CARD9 plays a key role in the regulation of the growth and differentiation of stem cells, which are cells that have the ability to develop into different types of cells in the body.

CARD9 is also a protein that is involved in the regulation of cellular processes that are critical for the development and maintenance of tissues. It is a protein that is involved in the regulation of cell cycle progression, which is the process by which cells grow and divide. CARD9 plays a key role in the regulation of the cell cycle, ensuring that cells divide and grow in a controlled and orderly manner.

CARD9 is also a protein that is involved in the regulation of cellular processes that are critical for the regulation of cell signaling pathways. It is a protein that is involved in the regulation of intracellular signaling pathways, which are the processes by which cells communicate with each other through the use of signaling molecules. CARD9 plays a key role in the regulation of these signaling pathways, ensuring that cells respond to different stimuli in a timely and effective manner.

CARD9 is also a protein that is involved in the regulation of cellular processes that are critical for the development and maintenance of tissues. It is a protein that is involved in the regulation of cell adhesion, which is the process by which cells stick together to form tissues. CARD9 plays a key role in the regulation of this process, ensuring that cells stick together to form tissues in a controlled and orderly manner.

In conclusion, CARD9 is a protein that plays a critical role in cell signaling pathways, cell death, tissue repair, and cellular processes that are critical for the development and maintenance of tissues. As a result, CARD9 may be a drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and diseases that are characterized by the regulation of cellular processes. Further research is needed to fully understand the role of CARD9 in these processes and to develop effective treatments for these diseases.

Protein Name: Caspase Recruitment Domain Family Member 9

Functions: Adapter protein that plays a key role in innate immune response against fungi by forming signaling complexes downstream of C-type lectin receptors (PubMed:26961233, PubMed:33558980). CARD9-mediated signals are essential for antifungal immunity against a subset of fungi from the phylum Ascomycota (PubMed:24231284, PubMed:25702837, PubMed:25057046, PubMed:26679537, PubMed:26961233, PubMed:26521038, PubMed:27777981, PubMed:29080677, PubMed:33558980). Transduces signals in myeloid cells downstream of C-type lectin receptors CLEC7A (dectin-1), CLEC6A (dectin-2) and CLEC4E (Mincle), which detect pathogen-associated molecular pattern metabolites (PAMPs), such as fungal carbohydrates, and trigger CARD9 activation (By similarity). Upon activation, CARD9 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11053425, PubMed:26488816, PubMed:31296852, PubMed:26961233, PubMed:33558980). CARD9 signaling in antigen-presenting cells links innate sensing of fungi to the activation of adaptive immunity and provides a cytokine milieu that induces the development and subsequent of interleukin 17-producing T helper (Th17) cells (PubMed:24231284). Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). CARD9 can also be engaged independently of BCL10: forms a complex with RASGRF1 downstream of C-type lectin receptors, which recruits and activates HRAS, leading to ERK activation and the production of cytokines (By similarity). Acts as an important regulator of the intestinal commensal fungi (mycobiota) component of the gut microbiota (PubMed:33548172). Plays an essential role in antifungal immunity against dissemination of gut fungi: acts by promoting induction of antifungal IgG antibodies response in CX3CR1(+) macrophages to confer protection against disseminated C.albicans or C.auris infection (PubMed:33548172). Also mediates immunity against other pathogens, such as certain bacteria, viruses and parasites; CARD9 signaling is however redundant with other innate immune responses (By similarity). In response to L.monocytogenes infection, required for the production of inflammatory cytokines activated by intracellular peptidoglycan: acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B (By similarity)

The "CARD9 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CARD9 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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