CAMK4: Potential Drug Target Or Biomarker (G814)

Target Name: CAMK4

NCBI ID: G814

CAMK4

CAMK4: Potential Drug Target Or Biomarker

CAMK4 (CAM kinase- GR) is a protein that is expressed in many different tissues throughout the body. It is involved in a variety of cellular processes, including cell signaling, protein synthesis, and stress response. Based on its structure and involvement in cellular processes, CAMK4 is a potential drug target or biomarker.

The kinase domain of CAMK4 is responsible for its catalytic activity. This domain contains a catalytic cycle that allows the protein to phosphorylate other proteins on its target. The most well-studied function of CAMK4 is its role in the regulation of protein synthesis. CAMK4 is known to play a negative role in the regulation of protein synthesis by the 26S ribosome, which is the machine that synthesizes proteins in the cell.

CAMK4 is involved in the negative regulation of the 26S ribosome by the A-site, which is a critical site for protein synthesis. This negative regulation allows CAMK4 to prevent the synthesis of too many proteins, which can be harmful to the cell. Additionally, CAMK4 is involved in the regulation of protein degradation, which is important for maintaining the homeostasis of the cell.

CAMK4 is also involved in the regulation of cellular stress response. Stress can be caused by a variety of factors, including changes in the environment, UV radiation, and certain drugs. CAMK4 is involved in the regulation of stress response by the stress-protein kinase pathway. This pathway allows the cell to respond to stress by producing stress-protein, which can help to protect the cell from damage.

CAMK4 is also involved in the regulation of cell signaling. It is a negative regulator of the MAPK/ERK signaling pathway, which is involved in a variety of cellular processes, including cell growth, differentiation, and survival. Additionally, CAMK4 is involved in the regulation of the PI3K/AKT signaling pathway, which is involved in the regulation of cell survival and metabolism.

CAMK4 is also a potential biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and mood disorders. Its involvement in the regulation of protein synthesis, stress response, and cell signaling makes it a promising target for the development of new drugs. Additionally, its well-studied function in the regulation of protein synthesis makes it an attractive candidate for the development of new therapies for diseases that are characterized by protein misfolding, such as cancer and neurodegenerative diseases.

In conclusion, CAMK4 is a protein that is involved in a variety of cellular processes that are important for the regulation of protein synthesis, stress response, and cell signaling. Its well-studied function in these processes makes it a potential drug target or biomarker for a variety of diseases. Further research is needed to fully understand its role in cellular processes and its potential as a drug target.

Protein Name: Calcium/calmodulin Dependent Protein Kinase IV

Functions: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18

The "CAMK4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CAMK4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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