CAMSAP2: A Potential Drug Target and Biomarker (G23271)

Target Name: CAMSAP2

NCBI ID: G23271

CAMSAP2

Other Name(s): CAMSAP2 variant 1 | Calmodulin-regulated spectrin-associated protein 1-like protein 1 | CAMSAP2 variant 3 | Calmodulin regulated spectrin associated protein family member 2, transcript variant 3 | CAMSAP2 variant 2 | CAMP2_HUMAN | RP11-93N17.1 | calmodulin-regulated spectrin-associated protein 1-like protein 1 | Calmodulin regulated spectrin-associated protein 1-like 1 | Calmodulin regulated spectrin associated protein family member 2, transcript variant 1 | Calmodulin-regulated spectrin-associated protein 2 | Calmodulin-regulated spectrin-associated protein 2 (isoform 3) | Calmodulin-regulated spectrin-associated protein 2 (isoform 1) | CAMSAP1L1 | Calmodulin-regulated spectrin-associated protein 2 (isoform 2) | Calmodulin regulated spectrin associated protein family member 2, transcript variant 2 | KIAA1078 | calmodulin regulated spectrin associated protein family member 2

CAMSAP2: A Potential Drug Target and Biomarker

CAMSAP2 (CAMylated-SAP2) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the SAP2 family, which includes other proteins that play crucial roles in cell signaling pathways. The identification of CAMSAP2 as a potential drug target and biomarker has significant implications for the development of new treatments for a variety of diseases.

CAMSAP2 Functions as a signaling molecule

CAMSAP2 is a protein that can interact with various signaling molecules, including TGF-β1, NF-kappa-B, and PI3K. These molecules are involved in a wide range of cellular processes, including cell growth, differentiation, and inflammation. CAMSAP2 has been shown to regulate the activity of these signaling molecules, which suggests that it plays a role in the regulation of cellular processes that are important for human health and disease.

One of the key functions of CAMSAP2 is its role in the regulation of cell signaling pathways. It has been shown to interact with various signaling molecules, including TGF-β1, which is involved in cell growth and differentiation. CAMSAP2 has been shown to regulate the activity of TGF-β1, which is important for the development and maintenance of tissues and organs.

Another function of CAMSAP2 is its role in the regulation of inflammation. It has been shown to interact with various signaling molecules, including NF-kappa-B, which is involved in the regulation of inflammation and immune responses. CAMSAP2 has been shown to regulate the activity of NF-kappa-B, which is important for the regulation of inflammation and the immune response.

CAMSAP2 as a potential drug target

The identification of CAMSAP2 as a potential drug target has significant implications for the development of new treatments for a variety of diseases. CAMSAP2 has been shown to play a role in the regulation of cellular processes that are important for human health and disease. Identifying its potential drug target and biomarker has led to the development of new treatments for diseases such as cancer, neurodegenerative diseases, and autoimmune diseases.

CAMSAP2 has also been shown to play a role in the regulation of the immune response. It has been shown to interact with various signaling molecules, including TGF-β1, which is involved in the regulation of cell signaling pathways. CAMSAP2 has been shown to regulate the activity of TGF-β1, which is important for the development and maintenance of tissues and organs.

CAMSAP2 as a potential biomarker

The identification of CAMSAP2 as a potential drug target and biomarker has significant implications for the development of new diagnostic tests and treatments for diseases. CAMSAP2 has been shown to play a role in the regulation of cellular processes that are important for human health and disease. Identifying its potential drug target and biomarker has led to the development of new treatments for diseases such as cancer, neurodegenerative diseases, and autoimmune diseases.

Conclusion

CAMSAP2 is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the SAP2 family, which includes other proteins that play crucial roles in cell signaling pathways. The identification of CAMSAP2 as a potential drug target and biomarker has significant implications for the development of new treatments for a variety of diseases. Further research is needed to fully understand the functions of CAMSAP2 and its potential as a drug target and biomarker.

Protein Name: Calmodulin Regulated Spectrin Associated Protein Family Member 2

Functions: Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242)

The "CAMSAP2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CAMSAP2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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