Regulation of Actin Filament Stability: CAPG as A Potential Drug Target

Target Name: CAPG

NCBI ID: G822

CAPG

Regulation of Actin Filament Stability: CAPG as A Potential Drug Target

CAPG, or Capping protein (actin filament), is a protein that plays a critical role in the structure and function of actin filaments, which are the building blocks of muscle cells. It is a member of the F-type actinin family, which includes several other proteins that regulate actin filament dynamics and play important roles in various cellular processes.

One of the unique features of CAPG is its ability to regulate the stability of actin filaments. Actin filaments are composed of a protein filament and a nucleotide that binds to the protein. The nucleotide binds to a specific amino acid residue on the protein, while the protein filament provides a structural framework for the nucleotide to bind to. The stability of the nucleotide-protein complex is critical for the proper functioning of the actin filament, as high levels of stability can influence the speed and efficiency of muscle contractions.

CAPG is known for its ability to regulate the stability of actin filaments by modulating the interactions between the nucleotide and the protein filament. It does this through a unique mechanism, where it adds a hydrophobic side chain to the protein filament. This side chain interacts with the nucleotide and disrupts its binding to the protein, causing the nucleotide to become more susceptible to degradation. This mechanism allows CAPG to regulate the stability of actin filaments without altering the activity of the nucleotide or the protein itself.

CAPG is also known for its role in the regulation of actin filament dynamics. It does this by influencing the stability of the nucleotide-protein complex and the strength of the nucleotide-protein bonds. By modulating these interactions, CAPG is able to regulate the rate at which nucleotides are released from the protein filament and the rate at which they are re-bound. This allows for a precise control over the number of nucleotides available for interaction with the nucleotide-protein complex, which is critical for the stability of the actin filament.

CAPG is also involved in the regulation of muscle cell growth and differentiation. It does this by influencing the distribution of nucleotides within the muscle cell, which can affect the rate of protein synthesis and the process of cell division.

In addition to its role in regulating actin filament dynamics, CAPG is also a potential drug target and biomarker. Its unique mechanism of regulating nucleotide stability has led to a great interest in its potential as a therapeutic agent, particularly for diseases that involve actin filament dysfunction, such as muscle-wasting diseases, neurodegenerative diseases, and cancer.

CAPG has also been shown to be involved in various signaling pathways. For example, it has been shown to be involved in the regulation of the TGF-β pathway, which is a well-known regulator of cell growth and differentiation. Additionally, CAPG has been shown to be involved in the regulation of the Wnt pathway, which is involved in the regulation of cell growth and the development of various tissues.

In conclusion, CAPG is a protein that plays a critical role in the structure and function of actin filaments. Its unique mechanism of regulating nucleotide stability and its involvement in various signaling pathways make it a potential drug target and biomarker. Further research is needed to fully understand the role of CAPG in the regulation of actin filament dynamics and its potential as a therapeutic agent.

Protein Name: Capping Actin Protein, Gelsolin Like

Functions: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA

The "CAPG Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CAPG comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets