CAPRIN1: A Versatile Protein as A Drug Target (G4076)

Target Name: CAPRIN1

NCBI ID: G4076

CAPRIN1

CAPRIN1: A Versatile Protein as A Drug Target

CAPRIN1 (RNG105) is a protein that is expressed in various tissues of the human body, including the brain, heart, liver, and kidneys. It is a member of the caprin gene family, which encodes a family of conserved cytoskeleton-associated proteins. CAPRIN1 is known for its role in regulating the cytoskeleton organization and stability, which is essential for many cellular processes, including cell division, migration, and invasion.

Recent studies have identified CAPRIN1 as a potential drug target for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and function have made it an attractive target for drug development due to its potential to modulate cellular processes that contribute to the development and progression of these diseases.

One of the key reasons for the potential of CAPRIN1 as a drug target is its versatile structure. CAPRIN1 is a cytoplasmic protein that can be expressed in various cell types, making it a versatile target for small molecules. Its cytoplasmic localization allows for the targeting of CAPRIN1-expressing cells, and its accessibility to various drug compounds has led to the development of a wide range of potential therapeutic agents.

Additionally, CAPRIN1's role in regulating cytoskeleton organization and stability makes it an attractive target for diseases that are characterized by disruptions in cellular organization and stability. For example, CAPRIN1 has been shown to play a role in the regulation of microtubule dynamics and stability, which is essential for the proper functioning of many cellular processes. Disruptions in microtubule dynamics and stability have been linked to the development and progression of various diseases, including neurodegenerative diseases.

Another potential mechanism by which CAPRIN1 may contribute to the development and progression of diseases is its role in cell signaling pathways. CAPRIN1 has been shown to play a role in several signaling pathways that are involved in the regulation of cellular processes, including cell proliferation, migration , and invasion. Its involvement in these signaling pathways makes it a potential target for drugs that are designed to disrupt these pathways and contribute to the development and progression of diseases.

In conclusion, CAPRIN1 is a protein that has the potential to be a drug target for various diseases due to its unique structure and function. Its versatility and accessibility as a target make it an attractive candidate for drug development. Further research is needed to fully understand the role of CAPRIN1 in cellular processes and its potential as a drug target.

Protein Name: Cell Cycle Associated Protein 1

Functions: mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:17210633, PubMed:31439799). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:31439799, PubMed:34074792, PubMed:36040869). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (PubMed:31439799). Binds directly and selectively to MYC and CCND2 mRNAs (PubMed:17210633). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (PubMed:17210633)

The "CAPRIN1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CAPRIN1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets