Characterization of PUS3, A Potential Drug Target for Neurodegenerative Diseases and Cancer

Target Name: PUS3

NCBI ID: G83480

PUS3

Characterization of PUS3, A Potential Drug Target for Neurodegenerative Diseases and Cancer

PUS3 (FKSG32) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the PUS family of proteins, which are known for their role in cell signaling and signaling pathways. PUS3 has been identified as a potential drug target and has been shown to play a role in a variety of biological processes, including neurodegenerative diseases, cancer, and inflammation.

The PUS family of proteins was identified in the late 1980s based on the discovery of the protein PUS1, which was shown to be involved in the regulation of cell growth and differentiation. Subsequent studies have shown that PUS proteins are involved in a wide range of cellular processes, including cell signaling pathways, cytoskeletal organization, and chromatin regulation. PUS3 is one of the most well-studied PUS proteins, and its functions and interactions with other proteins have been extensively characterized.

PUS3 is a 21-kDa protein that is expressed in a variety of tissues, including the brain, heart, and kidneys. It is a member of the PUS family of proteins, which are known for their role in cell signaling and signaling pathways. PUS3 has been shown to play a role in a variety of biological processes, including neurodegenerative diseases, cancer, and inflammation.

One of the key functions of PUS3 is its role in the regulation of the actin cytoskeleton. Actin is a protein that is involved in the structure and function of cells, and the cytoskeleton is the network of actin filaments that provides structural support to the cell. PUS3 is known to play a role in the regulation of actin cytoskeletal organization by interacting with the protein tyrosine kinase Fyn. This interaction between PUS3 and Fyn allows PUS3 to regulate the distribution of actin filaments in the cytoskeleton and to influence the formation of tight junctions between cells.

In addition to its role in cytoskeletal regulation, PUS3 is also involved in the regulation of a variety of cellular processes, including cell signaling pathways, DNA replication, and apoptosis. For example, PUS3 has been shown to play a role in the regulation of the NF-kappa-B signaling pathway, a pathway that is involved in inflammation and stress responses. PUS3 has also been shown to interact with the protein heat shock protein Hsp70, which is involved in the regulation of protein folding and stability.

PUS3 has also been shown to play a role in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. These conditions are characterized by the progressive loss of brain cells and the development of neurofibrillary tangles, which are thought to contribute to the symptoms of these conditions. PUS3 has been shown to interact with the protein tau, which is involved in the regulation of the formation of neurofibrillary tangles. This interaction between PUS3 and tau suggests that PUS3 may play a role in the regulation of neurofibrillary tangles and in the development of neurodegenerative diseases.

In addition to its role in neurodegenerative diseases, PUS3 has also been shown to be involved in the regulation of cancer. For example, PUS3 has been shown to interact with the protein p53, which is involved in the regulation of DNA replication and apoptosis. This interaction between PUS3 and p53 suggests that PUS3 may play a role in the regulation of DNA replication and apoptosis in cancer cells.

Finally, PUS3 has also been shown to play a role in the regulation of inflammation. For example, PUS3 has been shown to interact with the protein NF-kappa-B, which is involved in the regulation of inflammation and immune responses. This interaction between PUS3 and NF-kappa-B suggests that PUS3 may play a role in the regulation of inflammation in immune cells.

Overall, PUS3 is a well-studied protein that is involved in a

Protein Name: Pseudouridine Synthase 3

Functions: Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs

The "PUS3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PUS3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets