Understanding The Role of Histone H4 in Cancer and Cell Signaling

Target Name: H4C6

NCBI ID: G8361

H4C6

Other Name(s): Histone H4 | histone cluster 1, H4f | H4C14 | H4FC | translation initiation factor IF-2-like | H4C8 | H4_HUMAN | H4C12 | histone 1, H4f | H4 | H4C11 | H4C9 | H4C5 | H4 histone family, member C | histone cluster 1 H4 family member f | H4C16 | H4C15 | H4C3 | H4C1 | H4/c | H4C4 | H4C13 | H4C2 | HIST1H4F | H4 clustered histone 6 | H4-16

Understanding The Role of Histone H4 in Cancer and Cell Signaling

Histone H4 (H4) is a protein that plays a critical role in the regulation of gene expression and cell signaling. It is a key component of histones, which are small non-coding RNAs that make up the nucleosome, the basic unit of chromatin. Histones help to keep the chromosome in a compact, organized structure, and they also play a role in regulating the expression of genes.

H4 is one of the four histone proteins that make up the nucleosome. It is a small, 20-kDa protein that consists of four subunits. The subunits are held together by disulfide bonds, and they have a characteristic Rossmann-fold structure that allows them to interact with other proteins.

One of the key functions of H4 is its role in regulating gene expression. Histones can bind to specific DNA sequences and regulate the activity of transcription factors, which are proteins that help to turn on or off gene expression. For example, H4 has been shown to play a role in regulating the expression of the gene involved in the development and progression of cancer.

Another function of H4 is its role in cell signaling. Histones can interact with signaling proteins, which are proteins that transmit signals from the cell surface to inside the cell. For example, H4 has been shown to play a role in regulating the activity of the protein known as NF-kappa-B, which is involved in inflammation and stress responses.

H4 is also involved in the regulation of cell division. Histones can help to keep the chromosomes in the correct position during cell division, which is important for the proper formation of new cells.

Despite its importance, H4 is not well understood. little is known about the specific functions of H4 and its role in the cell.

Research into H4 has led to the identification of several potential drug targets. One of the main targets is the kinase inhibitor, an drug that inhibits the activity of protein kinases, which are enzymes that can activate or inhibit the activity of other proteins. Researchers have found that H4 plays a role in the regulation of kinase activity, and that inhibiting H4 activity may be a useful way to treat some types of cancer.

Another potential drug target for H4 is the G protein-coupled receptor (GPCR), a type of receptor that plays a critical role in cellular signaling. Researchers have found that H4 can interact with GPCRs and that this interaction may be involved in the regulation of cellular signaling. This suggests that H4 may be a useful target for some types of GPCR-mediated diseases.

Additionally, H4 has also been suggested as a potential biomarker for some types of cancer. The H4 protein is expressed in many types of cancer, and its levels can be used as a marker for the disease. This suggests that H4 may be an attractive target for some types of cancer treatment.

In conclusion, H4 is a protein that plays a critical role in the regulation of gene expression, cell signaling and cell division. Its role in these processes makes it an attractive target for drug development. The identification of potential drug targets and biomarkers for H4 suggests that H4 may be a useful target for some types of cancer and other diseases. Further research is needed to fully understand the functions of H4 and its potential as a drug target.

Protein Name: H4 Clustered Histone 6

Functions: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

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