RBM4B: A Potential Drug Target for Neurodegenerative Disorders

Target Name: RBM4B

NCBI ID: G83759

RBM4B

RBM4B: A Potential Drug Target for Neurodegenerative Disorders

RNA-Binding Module 4B (RBM4B) is a protein that plays a critical role in the regulation of gene expression and has been identified as a potential drug target in the disease neurodegenerative disorders. RBM4B is a key component of the RNA-protein complex known as the RNA-binding module (RBM), which is a protein-protein interaction domain found in the cytoplasm of many eukaryotic cells. The RBM is responsible for the recognition and interaction of RNA molecules with their protein partners, thereby regulating gene expression.

The RBM is a highly conserved protein that is found in various organisms, including bacteria, yeast, plants, and animals. It is composed of multiple domains, including an N-terminal domain that contains a leucine-rich repeat, a central domain that contains a Rossmann-fold and a C-terminal domain that contains a handle-like structure. The N-terminal domain is responsible for the formation of the RBM complex, while the C-terminal domain is involved in the stability and subcellular localization of the RBM.

RBM4B has been shown to play a crucial role in the regulation of gene expression in various organisms. For example, studies have shown that RBM4B is involved in the regulation of gene expression in plants, where it has been shown to play a role in the regulation of photosynthesis and flower development. In addition, RBM4B has also been shown to be involved in the regulation of gene expression in animals, where it has been shown to play a role in the regulation of neuronal development and function.

The potential drug target status of RBM4B is supported by its high homophily, which means that it is likely to interact with similar molecules in the cell. This is consistent with the idea that RBM4B could be a drug target by targeting its interactions with specific proteins that are involved in the regulation of gene expression. Additionally, the fact that RBM4B is a protein that is expressed in a variety of tissues and cells also supports its potential as a drug target.

In conclusion, RBM4B is a protein that has been identified as a potential drug target due to its role in the regulation of gene expression. Its high homophily and the fact that it is expressed in a variety of tissues and cells make it an attractive target for drug development. Further research is needed to determine the specific mechanisms by which RBM4B functions as a drug target and to develop effective therapies for the treatment of neurodegenerative disorders.

Protein Name: RNA Binding Motif Protein 4B

Functions: Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity)

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•   general information;
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•   protein biological mechanisms;
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•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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