RBX1: A Protein with Potential as A Drug Target Or Biomarker (G9978)

Target Name: RBX1

NCBI ID: G9978

RBX1

RBX1: A Protein with Potential as A Drug Target Or Biomarker

RBX1 (RING-box protein 1) is a protein that is expressed in various tissues throughout the body, including the brain, heart, liver, and kidney. It is a member of the superfamily of RNA-binding proteins, which includes proteins that play a critical role in regulating gene expression.

One of the unique features of RBX1 is its ability to form a protein-protein interaction complex with other proteins, which is important for its function in cellular signaling. This interaction between RBX1 and other proteins is mediated by its conserved CB domain (conserved combined domain) and its variable region.

RBX1 has been shown to play a critical role in the regulation of cellular processes that are important for brain development, function, and disease. For example, studies have shown that RBX1 is involved in the regulation of synaptic plasticity, which is the ability of the brain to change and adapt over time. RBX1 has also been shown to be involved in the regulation of neuronal excitability, which is important for the proper functioning of the brain.

In addition to its role in cellular signaling, RBX1 has also been shown to have potential as a drug target or biomarker. One way to target RBX1 is to use small molecules that can modulate its activity, such as inhibitors of its phosphorylation or inhibitors of its protein-protein interaction. These small molecules can be used to treat a variety of diseases, including neurodegenerative disorders, psychiatric disorders, and cardiovascular disease.

Another way to use RBX1 as a biomarker is to use it as a gene therapy target. Through genetic engineering technology, foreign genes can be embedded into human cells, and this foreign gene can be recognized and combined by the RBX1 protein, thereby achieving the purpose of treating diseases.

RBX1 also has been shown to be involved in the regulation of cellular processes that are important for tissue repair and regeneration. This is important because many diseases, such as cancer, are caused by the failure of tissues to repair themselves. By targeting RBX1 and modulating its activity, researchers may be able to develop new treatments for these diseases.

Overall, RBX1 is a protein that has the potential to be a drug target or biomarker. Its unique ability to form a protein-protein interaction complex and its involvement in the regulation of cellular processes that are important for brain development and function make it an attractive target for research and treatment. Further studies are needed to fully understand its role and potential as a drug target or biomarker.

Protein Name: Ring-box 1

Functions: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair (PubMed:10230407, PubMed:10579999, PubMed:15983046, PubMed:16678110, PubMed:19112177, PubMed:19679664, PubMed:23455478, PubMed:27565346, PubMed:29769719, PubMed:11961546, PubMed:22748924). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (PubMed:27565346). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Recruits the E2 ubiquitin-conjugating enzyme CDC34 to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A (PubMed:19920177)

The "RBX1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RBX1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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