SPAG1: A Protein Targeted for Therapies (G6674)

Target Name: SPAG1

NCBI ID: G6674

SPAG1

SPAG1: A Protein Targeted for Therapies

SPAG1 (Dynamin Axonemal Assembly Factor 13) is a protein that plays a crucial role in the assembly of axons, which are the long, thread-like structures that carry nerve signals away from the brain. Mutations in SPAG1 have been linked to a range of neurological and developmental disorders, including spinal muscular atrophy, which is a genetic disorder that affects muscle strength and function.

In addition to its role in axonemal assembly, SPAG1 is also involved in the regulation of cell division and has been shown to play a role in the development and maintenance of cancer. These properties make it an attractive target for drug development, particularly for treatments aimed at targeting spinal muscular atrophy and other disorders that are characterized by the misfolding and dysfunction of proteins.

The study of SPAG1 and its associated diseases began in the late 1980s, when researchers identified a protein that seemed to be involved in the assembly of axons. This protein, named SPAG1, was shown to be highly conserved across different species and to be involved in the regulation of axonemal assembly. Since then, numerous studies have confirmed the role of SPAG1 in the assembly of axons and have identified its potential as a drug target.

SPAG1 is a member of the family of proteins known as kinesin-like proteins, which are involved in the regulation of cell division and the movement of organelles within cells. These proteins are characterized by a protein domain that contains a nucleotide-binding oligomerization (NBO) domain, which is responsible for the protein's ability to bind to DNA.

In addition to its involvement in the regulation of cell division, SPAG1 is also involved in the regulation of axonemal assembly and has been shown to play a role in the development and maintenance of spinal muscular atrophy. This is because SPAG1 is highly conserved across different species and is able to function in a wide range of cellular contexts.

One of the challenges in studying SPAG1 is its ability to function as a drug target, particularly given its involvement in the regulation of cell division and the development of diseases. However, researchers have made significant progress in understanding the protein's role in these processes and have identified several potential drug targets.

For example, studies have shown that SPAG1 is involved in the regulation of the assembly and disassembly of axons, which are the structures that carry nerve signals away from the brain. By targeting SPAG1, researchers have identified potential drug targets that could be used to treat spinal muscular atrophy and other disorders characterized by the misfolding and dysfunction of proteins.

Another potential drug target for SPAG1 is its role in the regulation of cell division. Studies have shown that SPAG1 is involved in the regulation of cell division in a variety of contexts, including the regulation of mitosis and meiosis. By targeting SPAG1, researchers have identified potential drug targets that could be used to treat a range of disorders, including cancer.

In addition to its potential as a drug target, SPAG1 is also an attractive biomarker for a variety of diseases. Its involvement in the regulation of axonemal assembly and cell division makes it a potential target for drugs aimed at treating spinal muscular atrophy and other disorders that are characterized by the misfolding and dysfunction of proteins.

Overall, SPAG1 is a protein that has significant potential as a drug target and as a biomarker for a variety of diseases. Its involvement in the regulation of axonemal assembly and cell division makes it an attractive target for drugs aimed at treating spinal muscular atrophy and other disorders. Further research is needed to fully understand the protein's role in these processes and to identify effective treatments.

Protein Name: Sperm Associated Antigen 1

Functions: May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity

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