CPNE1: A Potential Drug Target for Various Diseases (G8904)

Target Name: CPNE1

NCBI ID: G8904

CPNE1

CPNE1: A Potential Drug Target for Various Diseases

Chromobindin 17 (CPNE1) is a protein that is expressed in various tissues of the human body, including the brain, spleen, and peripheral blood cells. It is a member of the Chromobindin family of proteins, which are known for their role in the regulation of DNA damage and repair.

The discovery of CPNE1 as a potential drug target or biomarker for various diseases has significant implications for the development of new treatments. Chromobindin 17 has been shown to be involved in a number of important cellular processes, including DNA replication, repair, and apoptosis. Its expression has also been linked to a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key reasons for the interest in CPNE1 as a drug target is its role in the regulation of DNA damage and repair. Chromobindin 17 has been shown to play a critical role in the repair of DNA double-strand breaks, which can occur as a result of damage caused by factors such as radiation, chemicals, or errors during DNA replication. By regulating the repair of these breaks, CPNE1 helps to prevent the buildup of genetic mutations that can lead to a range of diseases.

Another important function of CPNE1 is its role in apoptosis, which is the process by which cells undergo programmed cell death. During apoptosis, CPNE1 helps to coordinate the release of signaling molecules that induce the cell to undergo death. This is important for the regulation of tissue homeostasis and for the removal of damaged or dysfunctional cells.

In addition to its role in DNA damage repair and apoptosis, CPNE1 is also involved in the regulation of cell cycle progression. It has been shown to play a critical role in the G1 phase of the cell cycle, which is the stage of growth and development when cells prepare for cell division. By regulating the G1 phase, CPNE1 helps to ensure that cells are able to divide and grow properly.

The expression of CPNE1 has also been linked to a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, studies have shown that high levels of CPNE1 expression are associated with poor prognosis in patients with pancreatic cancer, a common form of cancer that is often treated with chemotherapy. Similarly, research has suggested that high levels of CPNE1 expression may be a predictor of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

In conclusion, the discovery of CPNE1 as a potential drug target or biomarker for various diseases has significant implications for the development of new treatments. With further research, it is likely that the role of CPNE1 in the regulation of DNA damage and repair, as well as its involvement in apoptosis and cell cycle progression, will be further understood. This knowledge will be valuable for the development of new treatments for a wide range of diseases.

Protein Name: Copine 1

Functions: Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740)

The "CPNE1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CPNE1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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