CIAO1: A Protein with Potential as A Drug Target and Biomarker

Target Name: CIAO1

NCBI ID: G9391

CIAO1

CIAO1: A Protein with Potential as A Drug Target and Biomarker

CIAO1 (WD repeat domain 39) is a protein that is expressed in various tissues throughout the body. It is a key player in the development and maintenance of the nervous system, and has been linked to a number of neurological disorders.

One of the most promising aspects of CIAO1 is its potential as a drug target. The WD repeat domain is a conserved region of the protein that is found in a variety of organisms, including humans. This suggests that it may be a good candidate for small molecules that can modulate its activity and potentially treat the corresponding class of diseases.

Additionally, research has also shown that CIAO1 is involved in a number of signaling pathways that are important for brain development and function. It has been shown to play a role in the development of neurotrophic enoids, which are important for the survival and growth of neurons.

Another promising aspect of CIAO1 is its potential as a biomarker. The development of biomarkers for neurodegenerative diseases has been a major focus in recent years, and CIAO1 may be a useful candidate for this purpose. Its expression has been shown to be affected by a number of neurodegenerative diseases, including Alzheimer's and Parkinson's disease. This suggests that it may be a good indicator of the severity of these conditions and could potentially be used as a diagnostic tool.

In addition to its potential as a drug target and biomarker, CIAO1 is also of interest to researchers as a potential therapeutic target for a variety of neurological disorders. The development of small molecules that can modulate CIAO1 activity may provide new treatments for a wide range of neurodegenerative diseases.

Overall, CIAO1 is a protein that has significant potential as a drug target and biomarker. Its conserved WD repeat domain and involvement in key signaling pathways make it a promising candidate for small molecules that can modulate its activity. Further research is needed to fully understand its role in neurodegenerative diseases and to develop new treatments based on its properties.

Protein Name: Cytosolic Iron-sulfur Assembly Component 1

Functions: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:17937914, PubMed:23891004). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (PubMed:23891004). Seems to specifically modulate the transactivation activity of WT1 (PubMed:9556563). As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633)

The "CIAO1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CIAO1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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