Unlocking the Potential of PTPRZ1: A Promising Drug Target and Biomarker

Target Name: PTPRZ1

NCBI ID: G5803

PTPRZ1

Unlocking the Potential of PTPRZ1: A Promising Drug Target and Biomarker

Introduction

Phosphatidylinositol 4-phosphate (PIP4) is a crucial molecule in various cellular signaling pathways, including the PI3K-Akt signaling pathway. This pathway plays a vital role in cell survival, proliferation, and angiogenesis. One of the key components of this pathway is the protein Pyruvate Kinase (PK), which is involved in the phosphate orylation of the target protein Pyruvate. The Pyruvate Kinase gene (PKG) has four isoforms, Pyruvate Kinase alpha (PK伪), Pyruvate Kinase beta (PK尾), Pyruvate Kinase gamma (PK纬 ), and Pyruvate Kinase delta (PK未). Among them, Pyruvate Kinase gamma (PK纬) is the most abundant isoform in human cells and is often used as a drug target in the pharmaceutical industry due to its unique structure and function.

PTPRZ1 (Pyruvate Kinase Gamma-Binding Zinc Transporter 1) is a protein that is expressed in various tissues and cells, including brain, heart, liver, and pancreas. It is a member of the PK family and is responsible for transmitting signals from the PIP4 molecule to the PKG protein. The PTPRZ1 gene has four splice variants, which result in the production of four different isoforms of PKG. These isoforms have different half-lives and expression levels, and the most abundant isoform is PKG纬, which is the target of many pharmaceuticals , including those for the treatment of cancer, neurodegenerative diseases, and metabolic disorders.

The Role of PTPRZ1 in Cellular Signaling

PTPRZ1 is a key protein that participates in multiple processes of cell signaling. In the PK signaling pathway, PTPRZ1 plays a role in the early steps of signal transmission. When cells receive signal stimulation from the external environment, PTPRZ1 interacts with PKG纬 and transmits the signal. Subsequently, PKG纬 is phosphorylated, and its activity can be further regulated, resulting in the activation or inhibition of a series of downstream signaling pathways.

The relationship between PTPRZ1 and various diseases

Due to its important role in PK signaling pathway, PTPRZ1 has been widely studied for its role in various diseases. In cancer, PTPRZ1 is considered a potential therapeutic target. Many studies have shown that inhibiting PTPRZ1 can inhibit the growth and metastasis of cancer cells. In addition, the phosphorylation level of PKG纬 is also involved in neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. Therefore, these diseases have also been listed as potential therapeutic targets for PTPRZ1.

Pharmacological significance of PTPRZ1

Due to its role in a variety of diseases, PTPRZ1 has been extensively studied for its role in drug treatment. Currently, a variety of drugs have been developed and used to treat PTPRZ1-related diseases, including anti-tumor drugs, anti-neurodegenerative drugs, and hypoglycemic drugs. For example, gemcitabine is an antineoplastic drug originally developed to treat colorectal cancer. Later studies showed that gemcitabine can also inhibit the phosphorylation of PKG纬, thereby inhibiting the growth and metastasis of cancer cells. In addition, due to the role of PTPRZ1 in neurodegenerative diseases, some anti-neurodegenerative disease drugs have also been developed, such as anti-Parkinson's disease drugs and anti-Alzheimer's disease drugs.

Biological significance of PTPRZ1

In addition to its role in drug therapy, PTPRZ1 is also closely related to a variety of biological processes. For example, PTPRZ1 plays a role in cell proliferation and apoptosis and is related to the cell cycle. In addition, PTPRZ1 is also related to the apoptosis signaling pathway in cell apoptosis. In the metabolic process, PTPRZ1 also plays an important role.

Protein Name: Protein Tyrosine Phosphatase Receptor Type Z1

Functions: Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity)

The "PTPRZ1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PTPRZ1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets