Protein Tyrosine Phosphatase (PTPRH) Functions as A Drug Target Or Biomarker

Target Name: PTPRH

NCBI ID: G5794

PTPRH

Other Name(s): protein tyrosine phosphatase receptor type H | R-PTP-H | Receptor-type tyrosine-protein phosphatase H isoform 1 precursor (isoform 1) | Protein tyrosine phosphatase receptor type H, transcript variant 1 | Receptor-type tyrosine-protein phosphatase H isoform 2 precursor (isoform 2) | SAP1 | stomach cancer-associated protein tyrosine phosphatase 1 | Stomach cancer-associated protein tyrosine phosphatase 1 | transmembrane-type protein-tyrosine phosphatase type H | SAP-1 | Transmembrane-type protein-tyrosine phosphatase type H | PTPRH variant 1 | Protein tyrosine phosphatase receptor type H, transcript variant 2 | Receptor-type tyrosine-protein phosphatase H | PTPRH variant 2 | Stomach cancer-associated PTP | PTPRH_HUMAN

Protein Tyrosine Phosphatase (PTPRH) Functions as A Drug Target Or Biomarker

Protein tyrosine phosphatase (PTPRH) is a protein that is involved in the regulation of many cellular processes in the body. It is a protein that is found in many different cell types, including neurons, muscle cells, and immune cells. PTPRH is involved in a number of different cellular processes, including the regulation of signaling pathways, cell division, and the cell cycle.

One of the key functions of PTPRH is its role in the regulation of the MAPK/ERK signaling pathway. This signaling pathway is involved in many different cellular processes, including cell growth, differentiation, and response to stimuli. PTPRH is involved in the regulation of the MAPK/ERK signaling pathway by phosphorylating and dephosphorylating the protein known as p21.

Another function of PTPRH is its role in the regulation of the PI3K/AKT signaling pathway. This signaling pathway is involved in the regulation of many different cellular processes, including cell growth, differentiation, and survival. PTPRH is involved in the regulation of the PI3K/AKT signaling pathway by phosphorylating and dephosphorylating the protein known as p75.

PTPRH is also involved in the regulation of the S6 kinase signaling pathway. This signaling pathway is involved in the regulation of many different cellular processes, including DNA replication, gene expression, and cell cycle progression. PTPRH is involved in the regulation of the S6 kinase signaling pathway by phosphorylating and dephosphorylating the protein known as S6.

In addition to its role in the regulation of these signaling pathways, PTPRH is also involved in the regulation of many other cellular processes. It is involved in the regulation of cell division, the regulation of cell cycle progression, and the regulation of protein synthesis.

As a drug target or biomarker, PTPRH is a potential target for the development of new treatments for a number of different diseases. For example, PTPRH has been shown to be involved in the regulation of many different cellular processes, including the regulation of cell growth, differentiation, and survival. This suggests that it may be a useful target for the development of new treatments for diseases such as cancer, neurodegenerative diseases, and autoimmune disorders.

In addition to its potential as a drug target, PTPRH is also a potential biomarker for a number of different diseases. For example, it has been shown to be involved in the regulation of many different cellular processes, including the regulation of cell growth, differentiation, and survival. This suggests that it may be a useful biomarker for diseases such as cancer, neurodegenerative diseases, and autoimmune disorders.

Overall, PTPRH is a protein that is involved in the regulation of many different cellular processes. It is a potential drug target and biomarker for a number of different diseases. Further research is needed to fully understand the role of PTPRH in cellular processes and its potential as a drug and biomarker.

Protein Name: Protein Tyrosine Phosphatase Receptor Type H

Functions: Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of activity of Jurkat cells. Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response CEACAM20 (By similarity)

The "PTPRH Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PTPRH comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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